Oct4 Targets Regulatory Nodes to Modulate Stem Cell Function

Pearl A. Campbell; Carolina Perez-Iratxeta; Miguel A. Andrade-Navarro; Michael A. Rudnicki

doi:10.1371/journal.pone.0000553

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Open Access

Peer-reviewed

Research Article

Oct4 Targets Regulatory Nodes to Modulate Stem Cell Function

Pearl A. Campbell,

Affiliations Sprott Centre for Stem Cell Research, Ottawa Health Research Institute, Ottawa, Ontario, Canada, University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, Ontario, Canada
⨯
Carolina Perez-Iratxeta,

Affiliation Sprott Centre for Stem Cell Research, Ottawa Health Research Institute, Ottawa, Ontario, Canada
⨯
Miguel A. Andrade-Navarro,

Affiliations Sprott Centre for Stem Cell Research, Ottawa Health Research Institute, Ottawa, Ontario, Canada, University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, Ontario, Canada
⨯
Michael A. Rudnicki

*To whom correspondence should be addressed. E-mail: mrudnicki@ohri.ca

Affiliations Sprott Centre for Stem Cell Research, Ottawa Health Research Institute, Ottawa, Ontario, Canada, University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, Ontario, Canada
⨯

Oct4 Targets Regulatory Nodes to Modulate Stem Cell Function

Pearl A. Campbell,
Carolina Perez-Iratxeta,
Miguel A. Andrade-Navarro,
Michael A. Rudnicki

Published: June 20, 2007
https://doi.org/10.1371/journal.pone.0000553

About the Authors

Pearl A. Campbell

Affiliations Sprott Centre for Stem Cell Research, Ottawa Health Research Institute, Ottawa, Ontario, Canada, University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, Ontario, Canada

Carolina Perez-Iratxeta

Affiliation Sprott Centre for Stem Cell Research, Ottawa Health Research Institute, Ottawa, Ontario, Canada

Miguel A. Andrade-Navarro

Michael A. Rudnicki

*To whom correspondence should be addressed. E-mail: mrudnicki@ohri.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MR PC. Performed the experiments: PC. Analyzed the data: CP MA PC. Contributed reagents/materials/analysis tools: CP. Wrote the paper: MR MA PC.

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Stem cells
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Cell differentiation
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Gene regulation
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Chromatin
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Transcriptional control
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Apoptosis
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Gene expression
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Pluripotency
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