About the Authors

Jenny Fredriksson

Affiliation Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden

Dragi Anevski

Affiliations Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden, Department of Mathematical Sciences, Chalmers University of Technology, Göteborg, Sweden

Peter Almgren

Affiliation Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden

Marketa Sjögren

Affiliation Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden

Valeriya Lyssenko

Affiliation Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden

Joyce Carlson

Affiliation Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden

Bo Isomaa

Affiliation Folkhälsan Genetic Institute, Folkhälsan Research Center, Biomedicum, Helsinki and Malmska Municipal Health Care Center and Hospital, Jakobstad, Finland

Marja-Riitta Taskinen

Affiliation Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Finland

Leif Groop

Affiliations Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden, Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Finland, Research Program of Molecular Medicine, University of Helsinki, Helsinki, Finland

Marju Orho-Melander

To whom correspondence should be addressed. E-mail: marju.orho-melander@med.lu.se

Affiliation Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden

for the Botnia Study Group

Affiliations Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden, Department of Mathematical Sciences, Chalmers University of Technology, Göteborg, Sweden, Folkhälsan Genetic Institute, Folkhälsan Research Center, Biomedicum, Helsinki and Malmska Municipal Health Care Center and Hospital, Jakobstad, Finland, Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Finland, Research Program of Molecular Medicine, University of Helsinki, Helsinki, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LG MO JC BI. Performed the experiments: MS JF. Analyzed the data: PA DA MO JF. Contributed reagents/materials/analysis tools: LG VL MT MO MS JC BI. Wrote the paper: LG VL PA DA MT MO MS JF JC BI.