A preprint is a version of a scientific manuscript posted to a public server prior to peer review or formal publication in a scholarly journal. PLOS empowers authors to post preprints as a way to accelerate the dissemination of their research.

Authors are strongly encouraged to share their research on preprint servers and to provide links to their preprint during submission, and editors are advised to use comments posted on preprints and preprint reviews where applicable. Additionally, preprints on bioRxiv and medRxiv can have their files and metadata directly transferred to a relevant PLOS journal for a streamlined submission process.

PLOS makes the interaction between preprint servers and our journals as easy as possible, and we link our publications to the relevant preprint for authors. 

Learn more about the power of preprints
→ About preprints
→ Preprint pre-posting checklist
→ PLOS preprint FAQ

Many other preprint servers exist. See Open Science Foundation’s preprint archive search for a list of preprint servers. Some preprint servers accept preprints from any research study but many are specific to geographical regions or research disciplines.

Direct Transfer Service to PLOS

PLOS partners with Cold Spring Harbor Laboratory to make posting preprints in the life and medical sciences seamless and convenient.

Authors posting preprints to the bioRxiv or medRxiv preprint servers can choose to concurrently submit their manuscripts to a relevant PLOS journal through the direct transfer service. Learn more about posting a preprint and the direct transfer service offered by bioRxiv and medRxiv.

Updates to preprints

To ensure that readers are always accessing the latest version of the article, authors are encouraged to submit updates and revisions to the relevant preprint server directly.


If a concern arises about a published PLOS article with a related preprint, PLOS will evaluate the concern according to our standard editorial processes, taking into account any relevant comments available on the preprint.