Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study

• Shoya Iwanami ,

  Contributed equally to this work with: Shoya Iwanami, Keisuke Ejima, Alan S. Perelson, Shingo Iwami

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

  https://orcid.org/0000-0003-1474-5348

  ⨯
• Keisuke Ejima ,

  Contributed equally to this work with: Shoya Iwanami, Keisuke Ejima, Alan S. Perelson, Shingo Iwami

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: kejima@iu.edu (KE); iwami.iblab@bio.nagoya-u.ac.jp, iwamishingo@gmail.com (SI)

  Affiliation Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Indiana, United States of America

  https://orcid.org/0000-0002-1185-3987

  ⨯
• Kwang Su Kim,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

  https://orcid.org/0000-0001-6626-316X

  ⨯
• Koji Noshita,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan

  https://orcid.org/0000-0002-9510-5897

  ⨯
• Yasuhisa Fujita,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

  https://orcid.org/0000-0002-1720-3942

  ⨯
• Taiga Miyazaki,

  Roles Writing – review & editing

  Affiliation Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

  https://orcid.org/0000-0002-0962-5758

  ⨯
• Shigeru Kohno,

  Roles Writing – review & editing

  Affiliation Nagasaki University, Nagasaki, Japan

  ⨯
• Yoshitsugu Miyazaki,

  Roles Writing – review & editing

  Affiliation Department of Chemotherapy & Mycoses and Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan

  https://orcid.org/0000-0001-8942-0869

  ⨯
• Shimpei Morimoto,

  Roles Writing – review & editing

  Affiliation Institute of Biomedical Sciences, Nagasaki University, Japan

  https://orcid.org/0000-0002-5340-6851

  ⨯
• Shinji Nakaoka,

  Roles Writing – review & editing

  Affiliation Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan

  https://orcid.org/0000-0002-3277-9552

  ⨯
• Yoshiki Koizumi,

  Roles Writing – review & editing

  Affiliation National Center for Global Health and Medicine, Tokyo, Japan

  https://orcid.org/0000-0001-5124-1419

  ⨯
• Yusuke Asai,

  Roles Writing – review & editing

  Affiliation Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan

  ⨯
• Kazuyuki Aihara,

  Roles Funding acquisition, Writing – review & editing

  Affiliation International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan

  https://orcid.org/0000-0002-4602-9816

  ⨯
• Koichi Watashi,

  Roles Funding acquisition, Writing – review & editing

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Japan, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

  ⨯
• Robin N. Thompson,

  Roles Writing – review & editing

  Affiliations Mathematics Institute, University of Warwick, Coventry, United Kingdom, Zeeman Institute for Systems Biology and Infectious Disease Epidemiology Research, University of Warwick, Coventry, United Kingdom

  https://orcid.org/0000-0001-8545-5212

  ⨯
• Kenji Shibuya,

  Roles Writing – review & editing

  Affiliation Institute for Population Health, King’s College London, London, United Kingdom

  ⨯
• Katsuhito Fujiu,

  Roles Writing – original draft, Writing – review & editing

  Affiliations Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Department of Advanced Cardiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  ⨯
• Alan S. Perelson ,

  Contributed equally to this work with: Shoya Iwanami, Keisuke Ejima, Alan S. Perelson, Shingo Iwami

  Roles Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, New Mexico Consortium, Los Alamos, New Mexico, United States of America

  https://orcid.org/0000-0002-2455-0002

  ⨯
• Shingo Iwami ,

  Contributed equally to this work with: Shoya Iwanami, Keisuke Ejima, Alan S. Perelson, Shingo Iwami

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: kejima@iu.edu (KE); iwami.iblab@bio.nagoya-u.ac.jp, iwamishingo@gmail.com (SI)

  Affiliations Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan, Institute of Mathematics for Industry, Kyushu University, Fukuoka, Japan, Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan, NEXT-Ganken Program, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan, Science Groove Inc., Fukuoka, Japan

  https://orcid.org/0000-0002-1780-350X

  ⨯
•  [ ... ],
• Takaji Wakita

  Roles Writing – review & editing

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

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