Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study

Amit Kaura; Adam Hartley; Vasileios Panoulas; Ben Glampson; Anoop S. V. Shah; Jim Davies; Abdulrahim Mulla; Kerrie Woods; Joe Omigie; Anoop D. Shah; Mark R. Thursz; Paul Elliott; Harry Hemmingway; Bryan Williams; Folkert W. Asselbergs; Michael O’Sullivan; Graham M. Lord; Adam Trickey; Jonathan AC Sterne; Dorian O. Haskard; Narbeh Melikian; Darrel P. Francis; Wolfgang Koenig; Ajay M. Shah; Rajesh Kharbanda; Divaka Perera; Riyaz S. Patel; Keith M. Channon; Jamil Mayet; Ramzi Khamis

doi:10.1371/journal.pmed.1003911

Open Access

Peer-reviewed

Research Article

Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study

Amit Kaura,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations National Heart and Lung Institute, Imperial College London, London, United Kingdom, NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

https://orcid.org/0000-0002-6962-3199

⨯
Adam Hartley,

Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations National Heart and Lung Institute, Imperial College London, London, United Kingdom, NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

https://orcid.org/0000-0003-1431-2200

⨯
Vasileios Panoulas,

Roles Investigation

Affiliations National Heart and Lung Institute, Imperial College London, London, United Kingdom, NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

https://orcid.org/0000-0002-9894-9200

⨯
Ben Glampson,

Roles Data curation, Investigation, Resources, Software

Affiliation NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

https://orcid.org/0000-0002-5601-5581

⨯
Anoop S. V. Shah,

Roles Investigation, Methodology, Validation

Affiliations National Heart and Lung Institute, Imperial College London, London, United Kingdom, NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom, London School of Hygiene Tropical Medicine, London, United Kingdom

https://orcid.org/0000-0002-2825-3419

⨯
Jim Davies,

Roles Investigation

Affiliation NIHR Oxford Biomedical Research Centre, University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

https://orcid.org/0000-0003-4664-6862

⨯
Abdulrahim Mulla,

Roles Data curation, Investigation

Affiliation NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

https://orcid.org/0000-0002-5943-2348

⨯
Kerrie Woods,

Roles Investigation

Affiliation NIHR Oxford Biomedical Research Centre, University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

https://orcid.org/0000-0001-8106-8290

⨯
Joe Omigie,

Roles Investigation

Affiliation NIHR King’s Biomedical Research Centre, King’s College London and King’s College Hospital NHS Foundation Trust, London, United Kingdom
⨯
Anoop D. Shah,

Roles Investigation

Affiliation NIHR University College London Hospitals Biomedical Research Centre, University College London and University College London Hospitals NHS Foundation Trust, London, United Kingdom

https://orcid.org/0000-0002-8907-5724

⨯
Mark R. Thursz,

Roles Investigation

Affiliation NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Paul Elliott,

Roles Investigation

Affiliations NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom, Health Data Research, London Substantive Site, United Kingdom

https://orcid.org/0000-0002-7511-5684

⨯
Harry Hemmingway,

Roles Investigation

Affiliations NIHR University College London Hospitals Biomedical Research Centre, University College London and University College London Hospitals NHS Foundation Trust, London, United Kingdom, Health Data Research, London Substantive Site, United Kingdom

https://orcid.org/0000-0003-2279-0624

⨯
Bryan Williams,

Roles Investigation

Affiliation NIHR University College London Hospitals Biomedical Research Centre, University College London and University College London Hospitals NHS Foundation Trust, London, United Kingdom

https://orcid.org/0000-0002-8094-1841

⨯
Folkert W. Asselbergs,

Roles Investigation

Affiliation NIHR University College London Hospitals Biomedical Research Centre, University College London and University College London Hospitals NHS Foundation Trust, London, United Kingdom

https://orcid.org/0000-0002-1692-8669

⨯
Michael O’Sullivan,

Roles Investigation

Affiliation NIHR Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
⨯
Graham M. Lord,

Roles Investigation

Affiliation NIHR Manchester Biomedical Research Centre, University of Manchester and Manchester University NHS Foundation Trust, Manchester, United Kingdom
⨯
Adam Trickey,

Roles Investigation

Affiliation NIHR Bristol Biomedical Research Centre, University of Bristol and University Hospitals Bristol NHS Foundation Trust, London, United Kingdom

https://orcid.org/0000-0003-3462-2898

⨯
Jonathan AC Sterne,

Roles Investigation

Affiliation NIHR King’s Biomedical Research Centre, King’s College London and Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
⨯
Dorian O. Haskard,

Roles Investigation, Writing – review & editing

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Narbeh Melikian,

Roles Investigation

Affiliation NIHR King’s Biomedical Research Centre, King’s College London and King’s College Hospital NHS Foundation Trust, London, United Kingdom
⨯
Darrel P. Francis,

Roles Investigation

Affiliations National Heart and Lung Institute, Imperial College London, London, United Kingdom, NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

https://orcid.org/0000-0002-3410-0814

⨯
Wolfgang Koenig,

Roles Investigation, Writing – review & editing

Affiliations Deutsches Herzzentrum München, Technische Universität München, Munich, Germany and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany, Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany

https://orcid.org/0000-0002-2064-9603

⨯
Ajay M. Shah,

Roles Investigation

Affiliation NIHR King’s Biomedical Research Centre, King’s College London and King’s College Hospital NHS Foundation Trust, London, United Kingdom

https://orcid.org/0000-0002-6547-0631

⨯
Rajesh Kharbanda,

Roles Investigation

Affiliation NIHR Oxford Biomedical Research Centre, University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

https://orcid.org/0000-0002-5356-2395

⨯
Divaka Perera,

Roles Investigation

Affiliation NIHR Manchester Biomedical Research Centre, University of Manchester and Manchester University NHS Foundation Trust, Manchester, United Kingdom

https://orcid.org/0000-0001-6362-1291

⨯
Riyaz S. Patel,

Roles Investigation

Affiliation NIHR University College London Hospitals Biomedical Research Centre, University College London and University College London Hospitals NHS Foundation Trust, London, United Kingdom
⨯
Keith M. Channon,

Roles Investigation

Affiliation NIHR Oxford Biomedical Research Centre, University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⨯
Jamil Mayet ,

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: j.mayet@imperial.ac.uk

Affiliations National Heart and Lung Institute, Imperial College London, London, United Kingdom, NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

https://orcid.org/0000-0002-4665-6422

⨯
[ ... ],
Ramzi Khamis

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

Affiliations National Heart and Lung Institute, Imperial College London, London, United Kingdom, NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

https://orcid.org/0000-0003-4119-5193

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Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study

Amit Kaura, …
Adam Hartley,
Vasileios Panoulas,
Ben Glampson,
Anoop S. V. Shah,
Jim Davies,
Abdulrahim Mulla,
Kerrie Woods,
Joe Omigie,
Anoop D. Shah

Published: February 22, 2022
https://doi.org/10.1371/journal.pmed.1003911

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