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Cytotoxic T cells  
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Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming

Matthew L. Lawton, Melissa M. Inge, Benjamin C. Blum, Erika L. Smith-Mahoney, Dante Bolzan, Weiwei Lin, Christina McConney, Jacob Porter, Jarrod Moore, Ahmed Youssef, Yashasvi Tharani, Xaralabos Varelas, Gerald V. Denis, Wilson W. Wong, Dzmitry Padhorny, Dima Kozakov, Trevor Siggers, Stefan Wuchty, Jennifer Snyder-Cappione, Andrew Emili

Research Article | published 17 Dec 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002943

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CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells

Bianca Pellegrino, Keren David, Stav Rabani, Bar Lampert, Thuy Tran, Edward Doherty, Marta Piecychna, Roberto Meza-Romero, Lin Leng, Dov Hershkovitz, Arthur A. Vandenbark, Richard Bucala, Shirly Becker-Herman, Idit Shachar

Research Article | published 22 Nov 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002905

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Degrade to stay healthy—Proteolytic interplay during inflammation

Christian Münz

Primer | published 07 Mar 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002548

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Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity

Hassan Jamaleddine, Dakota Rogers, Geneviève Perreault, Jérémy Postat, Dhanesh Patel, Judith N. Mandl, Anmar Khadra

Research Article | published 01 Feb 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002465

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Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection

Lauren K. Quezada, Wenhao Jin, Yi Chia Liu, Eleanor S. Kim, Zhaoren He, Cynthia S. Indralingam, Tiffani Tysl, Lara Labarta-Bajo, Ellen J. Wehrens, Yeara Jo, Katelynn R. Kazane, Christopher Hattori, Elina I. Zuniga, Gene W. Yeo, John T. Chang

Short Reports | published 30 Jan 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3001983

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Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9 from the cell surface during HIV infection

Garett Dunsmore, Eliana Perez Rosero, Shima Shahbaz, Deanna M. Santer, Juan Jovel, Paige Lacy, Stan Houston, Shokrollah Elahi

Research Article | published 19 Aug 2021 PLOS Biology

https://doi.org/10.1371/journal.pbio.3001387

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The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA

Asif A. Dar, Keisuke Sawada, Joseph M. Dybas, Emily K. Moser, Emma L. Lewis, Eddie Park, Hossein Fazelinia, Lynn A. Spruce, Hua Ding, Steven H. Seeholzer, Paula M. Oliver

Research Article | published 01 Feb 2021 PLOS Biology

https://doi.org/10.1371/journal.pbio.3001041

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Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

Inga Kavazović, Hongya Han, Giulia Balzaretti, Erik Slinger, Niels A. W. Lemmermann, Anja ten Brinke, Doron Merkler, Jan Koster, Yenan T. Bryceson, Niek de Vries, Stipan Jonjić, Paul L. Klarenbeek, Bojan Polić, Eric Eldering, Felix M. Wensveen

Research Article | published 17 Mar 2020 PLOS Biology

https://doi.org/10.1371/journal.pbio.3000648

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Yap suppresses T-cell function and infiltration in the tumor microenvironment

Eleni Stampouloglou, Nan Cheng, Anthony Federico, Emily Slaby, Stefano Monti, Gregory L. Szeto, Xaralabos Varelas

Short Reports | published 13 Jan 2020 PLOS Biology

https://doi.org/10.1371/journal.pbio.3000591

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Cell generation dynamics underlying naive T-cell homeostasis in adult humans

Jeff E. Mold, Pedro Réu, Axel Olin, Samuel Bernard, Jakob Michaëlsson, Sanket Rane, Andrew Yates, Azadeh Khosravi, Mehran Salehpour, Göran Possnert, Petter Brodin, Jonas Frisén

Research Article | published 29 Oct 2019 PLOS Biology

https://doi.org/10.1371/journal.pbio.3000383

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TSC1/mTOR-controlled metabolic–epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis

Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie Lü, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng, Jinbo Yang, Hui Xiao

Research Article | published 21 Aug 2019 PLOS Biology

https://doi.org/10.1371/journal.pbio.3000420

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Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Karin Schaeuble, Hélène Cannelle, Stéphanie Favre, Hsin-Ying Huang, Susanne G. Oberle, Daniel E. Speiser, Dietmar Zehn, Sanjiv A. Luther

Short Reports | published 15 Jul 2019 PLOS Biology

https://doi.org/10.1371/journal.pbio.3000072

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TLR1/2 orchestrate human plasmacytoid predendritic cell response to gram+ bacteria

Salvatore Raieli, Coline Trichot, Sarantis Korniotis, Lucia Pattarini, Vassili Soumelis

Short Reports | published 24 Apr 2019 PLOS Biology

https://doi.org/10.1371/journal.pbio.3000209

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Quantitative assessment of cell population diversity in single-cell landscapes

Qi Liu, Charles A. Herring, Quanhu Sheng, Jie Ping, Alan J. Simmons, Bob Chen, Amrita Banerjee, Wei Li, Guoqiang Gu, Robert J. Coffey, Yu Shyr, Ken S. Lau

Methods and Resources | published 22 Oct 2018 PLOS Biology

https://doi.org/10.1371/journal.pbio.2006687

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The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

Konstantin Knoblich, Sara Cruz Migoni, Susan M. Siew, Elizabeth Jinks, Baksho Kaul, Hannah C. Jeffery, Alfie T. Baker, Muath Suliman, Katerina Vrzalikova, Hisham Mehenna, Paul G. Murray, Francesca Barone, Ye H. Oo, Philip N. Newsome, Gideon Hirschfield, Deirdre Kelly, Steven P. Lee, Biju Parekkadan, Shannon J. Turley, Anne L. Fletcher

Short Reports | published 04 Sep 2018 PLOS Biology

https://doi.org/10.1371/journal.pbio.2005046

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March 2025
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2324252627281
2345678
9101112131415
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March 2025
SuMoTuWeThFrSa
2324252627281
2345678
9101112131415
16171819202122
23242526272829
303112345