Leveraging mathematical modeling framework to guide regimen strategy for phage therapy
Fig 10
In silico experiments for two-phage sequential treatments.
Each curve simulates the total bacteria density (solid line) after adding one phage strain at MOI 1 at time 0, and a different phage strain at MOI 1 at time 8 hours. (A) LUZ19→PYO2 (pink); (B) PYO2→LUZ19 (blue); (C) LUZ19→E215 (yellow); (D) E215 →LUZ19 (green); (E) PYO2→E215 (orange); (F) E215→PYO2 (purple). (G-H) Comparison of double phage sequential treatments with different phage combinations, application order, and second dose timings. (G) The total bacterial density at 15 hours was used to measure the treatment’s ability to control the bacterial population density. (H) The proportion of the bacteria at 15 hours that are resistant to all treatment phages.