Leveraging mathematical modeling framework to guide regimen strategy for phage therapy
Fig 7
Double phage model numerical simulations.
(A-C) Double-phage simulations at MOI 0.5 per phage for: (A) LUZ19+PYO2, (B) LUZ19+E215, and (C) PYO2+E215. Phage concentrations are denoted with solid lines with LUZ19 (blue), PYO2 (green), and E215 (purple). For all the simulations, the black dashed line denotes the sensitive bacteria and the red solid line denotes total bacteria. Infected bacterial strains and single-phage resistant mutants are denoted by tall dashed lines and wide dashed lines respectively in colors corresponding to the target phages. The double-phage double-mutant strain is denoted with an orange dashed line.