Leveraging mathematical modeling framework to guide regimen strategy for phage therapy
Fig 5
In silico single phage modeling and parameter sensitivities.
(A-C) Single phage model numerical simulations: (A) LUZ19 only treatment, (B) PYO2 only treatment, and (C) E215 only treatment. For all the simulations, B(0) = 0.2, BI(0) = 0, BR(0) = 0, P(0) = 0.2, b = 382, and rn = 0.88. For each simulation, phage specific parameter values are in Table 1. (D-F) Sensitivity analysis for the single phage model of each phage parameter settings. The relative sensitivities of (D) LUZ19, (E) PYO2, and (F) E215 were analyzed as outlined in Appendix A.