Leveraging mathematical modeling framework to guide regimen strategy for phage therapy
Fig 3
In vitro and bioinformatic analyses of phage resistant PAO1 mutants.
(A) Heatmap representation of mutations identified using BRESEQ post phage treatment. Phage resistant mutations in genes besides LPS or pili are denoted as “other”. (B) Efficacy of plating comparison of wild-type PAO1 and phage resistant PAO1 strains. (C) Diagram of phage receptor binding mechanisms for each of the three phages. LUZ19 binds to type IV pili while phages PYO2 and E215 both bind to the LPS O-antigen.