Leveraging mathematical modeling framework to guide regimen strategy for phage therapy
Fig 2
(A) Heatmap representation of PAO1 treated with single phage strains LUZ19, PYO2, or E215 (MOI 1) and combination strains LUZ19+E215, LUZ19+PYO2, or PYO2+E215 (MOI 0.5 per phage). (B) Bacterial colony counts (CFU) post treatment with LUZ19 (solid) or PYO2 (dashed). (C) Area under the curve (AUC) estimated the amount of bacterial cell density after 28 h of treatment. Treatments denoted as “a” and “b” were significant to each other and all others. *p < 0.05