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Table of Contents: October 2004

Recent discoveries show that prion phenomena in both humans and yeast are determined by amyloid-like conformations of misfolded proteins, and similar conformations are associated with noninfectious diseases such as Alzheimer's. Shown are AFM images of new amyloid growth from the ends of epitope-labeled seeds encapsulated in diagrams of yeast cells. (See Collins, et al.)

Image Credit: Image by Angela DePace

Message from PLoS

Open Access As Public Policy

Andy Gass

Essay

Diversifying Selection in Plant Breeding

Susan McCouch

Unsolved Mystery

Why Are So Many Bird Flowers Red?

Miguel A Rodríguez-Gironés, Luis Santamaría

Journal Club

Hearing: Travelling Wave or Resonance?

Andrew Bell

Community Page

Research Articles

Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance

Steven D Mason, Richard A Howlett, Matthew J Kim, I. Mark Olfert, Michael C Hogan, Wayne McNulty, Reed P Hickey, Peter D Wagner, C. Ronald Kahn, Frank J Giordano, Randall S Johnson

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Genetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans

Tammie Bishop, Kah Weng Lau, Andrew C. R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliffe

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  1. A Novel Pathway for a Tumor Suppressor

Sterol-Derived Hormone(s) Controls Entry into Diapause in Caenorhabditis elegans by Consecutive Activation of DAF-12 and DAF-16

Vitali Matyash, Eugeni V Entchev, Fanny Mende, Michaela Wilsch-Bräuninger, Christoph Thiele, Arndt W Schmidt, Hans-Joachim Knölker, Samuel Ward, Teymuras V Kurzchalia

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  1. Key to Cholesterol's Role in Nematode Development

Mechanism of Association and Reciprocal Activation of Two GTPases

Shu-ou Shan, Robert M Stroud, Peter Walter

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  1. Keeping Proteins on Target

Mechanism of Prion Propagation: Amyloid Growth Occurs by Monomer Addition

Sean R Collins, Adam Douglass, Ronald D Vale, Jonathan S Weissman

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  1. A Mechanism of Prion Propagation

Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes

Joshua M Akey, Michael A Eberle, Mark J Rieder, Christopher S Carlson, Mark D Shriver, Deborah A Nickerson, Leonid Kruglyak

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  1. Spotting Signs of Natural Selection

Genetic Response to Climatic Change: Insights from Ancient DNA and Phylochronology

Elizabeth A Hadly, Uma Ramakrishnan, Yvonne L Chan, Marcel van Tuinen, Kim O'Keefe, Paula A Spaeth, Chris J Conroy

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  1. Do Genes Respond to Global Warming?

Genomic Insights into Methanotrophy: The Complete Genome Sequence of Methylococcus capsulatus (Bath)

Naomi Ward, Øivind Larsen, James Sakwa, Live Bruseth, Hoda Khouri, A. Scott Durkin, George Dimitrov, Lingxia Jiang, David Scanlan, Katherine H Kang, Matt Lewis, Karen E Nelson, Barbara Methé, Martin Wu, John F Heidelberg, Ian T Paulsen, Derrick Fouts, Jacques Ravel, Hervé Tettelin, Qinghu Ren, Tim Read, Robert T DeBoy, Rekha Seshadri, Steven L Salzberg, Harald B Jensen, Nils Kåre Birkeland, William C Nelson, Robert J Dodson, Svenn H Grindhaug, Ingeborg Holt, Ingvar Eidhammer, Inge Jonasen, Susan Vanaken, Terry Utterback, Tamara V Feldblyum, Claire M Fraser, Johan R Lillehaug, Jonathan A Eisen

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  1. The Genome of a Methane-Loving Bacterium

Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells

Teresa A Venezia, Akil A Merchant, Carlos A Ramos, Nathan L Whitehouse, Andrew S Young, Chad A Shaw, Margaret A Goodell

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  1. A Molecular Model of Blood Cell Renewal

A Neuroeconomics Approach to Inferring Utility Functions in Sensorimotor Control

Konrad P Körding, Izumi Fukunaga, Ian S Howard, James N Ingram, Daniel M Wolpert

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  1. We Move in Mysterious Ways

Identification of Birds through DNA Barcodes

Paul D. N Hebert, Mark Y Stoeckle, Tyler S Zemlak, Charles M Francis

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  2. DNA Barcoding: Promise and Pitfalls

The Program of Gene Transcription for a Single Differentiating Cell Type during Sporulation in Bacillus subtilis

Patrick Eichenberger, Masaya Fujita, Shane T Jensen, Erin M Conlon, David Z Rudner, Stephanie T Wang, Caitlin Ferguson, Koki Haga, Tsutomu Sato, Jun S Liu, Richard Losick

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Correspondence and Other Communications

Book Review%2FScience in the Media

Language Evolution

Szabolcs Számadó, Eörs Szathmáry