Revising Your Manuscript

Important information about submitting revisions to PLOS Biology


PLOS Biology is transitioning to a new submission system, Aperta™. Any manuscripts first submitted in Editorial Manager will continue to proceed through the peer review process (and revision process, if a revise decision is made) without switching systems. New manuscript submissions will be handled in Aperta.


If you have submitted a manuscript in Aperta and received a revise decision, please refer to the green boxes below for information about how the revision process works in Aperta.


Read more about Aperta.

Submission Instructions

If you are submitting a revised manuscript, include the following items with your revised submission:

Response to reviewers

Address the specific points made by each reviewer. Include your responses to all the reviewers’ and editors’ comments and list the changes you have made to the manuscript. Upload this as a “Response to reviewers” file.

Responding to reviewers in Aperta

When you receive a revise decision in Aperta, you will see a Revise Manuscript card added to your submission. This card contains the decision letter as well as a place to enter your point-by-point response to reviewers. You can also write your response to reviewers in a separate file and upload it to this card. Read more about submitting revisions in Aperta.

Revised manuscript file

Upload a clean copy of your revised manuscript. Upload this as your “Manuscript” file.

We encourage you to include a marked-up copy of your manuscript file showing the changes you have made since the original submission. The best way to show these changes is the “Track Changes” option in Microsoft Word. Upload this to the submission as a “Related Manuscript” file type.

Figures and supporting information files from your original submission will automatically transfer to your revised submission unless you choose to update and replace them. 

Uploading your revised manuscript file in Aperta

If you are submitting a revision in Aperta, submit your revised manuscript by adding it to the Upload Manuscript card. You do not need to include an additional marked-up copy. Read more about submitting revisions in Aperta.

Author Summary

Include a 150-200 word non-technical summary of the work as a separate file, uploaded as a Related Manuscript file, with the title “Author Summary.” Subject to editorial review, this short text is published with all research articles as a highlighted text box. 

Submitting the Author Summary in Aperta

If you are submitting a revision in Aperta, include the Author Summary in your manuscript file after the Abstract and before the Introduction. Read more about submitting revisions in Aperta.

Distinct from the scientific abstract, the Author Summary is included in the article to make findings accessible to an audience of both scientists and non-scientists. Ideally aimed to a level of understanding of an undergraduate student, the significance of the work should be presented simply, objectively, and without exaggeration.

Author should avoid the use of acronyms and complex scientific terms and write the text using a first person voice. Authors may benefit from consulting with a science writer or press officer to ensure they effectively communicate their findings to a general audience. 


Weinberger LS, Shenk T (2007) An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer. PLoS Biol 5(1): e9. doi:10.1371/journal.pbio.0050009

Kim Guisbert KS, Li H, Guthrie C (2007) Alternative 3′ Pre-mRNA Processing in Saccharomyces cerevisiae Is Modulated by Nab4/Hrp1 In Vivo. PLoS Biol 5(1): e6. doi:10.1371/journal.pbio.0050006


Include a brief statement about the work that is about 20-30 words (1-2 sentences) long and included at the bottom of the Author Summary document under the heading “Blurb.”

Submitting the Blurb in Aperta


If you are submitting a revision in Aperta, upload the Blurb as a separate document to the Supporting Information card, and mark the file as not for publication. Read more about submitting revisions in Aperta.

Note that the blurb is not published with the manuscript. It is used in our weekly and monthly Electronic Table of Contents notifications, sent out to users signed up to receive alerts from PLOS Biology, and on the journal homepage.

The blurb is subject to editorial changes. It should, without exaggeration, entice people to read your manuscript. It should not be redundant with the title and should not contain acronyms or abbreviations. 


During embryonic development of the motor system of Drosophila, motorneurons target their dendrites to different regions along the body axis in response to midline guidance cues.

A neuroimaging study reveals novel insights into how the brain responds to an anticipated event, such as a starting gun or responding to a green light.

Computational modeling and experimentation in a model system for actin-based force generation explain how actin networks initiate and maintain directional movement.

For further examples, please view the blurbs accompanying the articles on the homepage of PLOS Biology.