Table of Contents: January 2018

Constant cell renewal is required to maintain healthy organs during adult homeostasis. The highly conserved Hippo signaling pathway is essential for the regulation of basic cell behaviors that underlie tissue renewal, including cell proliferation, cell differentiation, and cell death. This study by de Sousa et al. explores the role of Hippo in planarians, flatworms that continuously alter their size depending on nutrient availability, and therefore have a high rate of cellular turnover. The researchers present evidence that the main role of Hippo in planarians is not to promote proliferation but rather to control the cell cycle and maintain a stable differentiated cell fate. The image shows overgrowth generated in the planarian Schmidtea mediterranea after inhibition of Hippo signaling. The tissue was immunostained using antibodies against actin (green) and β-catenin-2 (red), which allow visualization of the epidermal cells, and nuclei are stained with DAPI (blue).

Image Credit: Nidia de Sousa


The importance of being second

The PLOS Biology Staff Editors


Reconciling Pasteur and Darwin to control infectious diseases

Samuel Alizon, Pierre-Olivier Méthot

Research Articles

Climate change could drive marine food web collapse through altered trophic flows and cyanobacterial proliferation

Hadayet Ullah, Ivan Nagelkerken, Silvan U. Goldenberg, Damien A. Fordham

Contrasting impacts of competition on ecological and social trait evolution in songbirds

Jonathan P. Drury, Joseph A. Tobias, Kevin J. Burns, Nicholas A. Mason, Allison J. Shultz, Hélène Morlon

Population genomics of Mesolithic Scandinavia: Investigating early postglacial migration routes and high-latitude adaptation

Torsten Günther, Helena Malmström, Emma M. Svensson, Ayça Omrak, Federico Sánchez-Quinto, Gülşah M. Kılınç, Maja Krzewińska, Gunilla Eriksson, Magdalena Fraser, Hanna Edlund, Arielle R. Munters, Alexandra Coutinho, Luciana G. Simões, Mário Vicente, Anders Sjölander, Berit Jansen Sellevold, Roger Jørgensen, Peter Claes, Mark D. Shriver, Cristina Valdiosera, Mihai G. Netea, Jan Apel, Kerstin Lidén, Birgitte Skar, Jan Storå, Anders Götherström, Mattias Jakobsson

Structure, function, and control of the human musculoskeletal network

Andrew C. Murphy, Sarah F. Muldoon, David Baker, Adam Lastowka, Brittany Bennett, Muzhi Yang, Danielle S. Bassett

Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development

Sébastien Darras, Jens H. Fritzenwanker, Kevin R. Uhlinger, Ellyn Farrelly, Ariel M. Pani, Imogen A. Hurley, Rachael P. Norris, Michelle Osovitz, Mark Terasaki, Mike Wu, Jochanan Aronowicz, Marc Kirschner, John C. Gerhart, Christopher J. Lowe

Hippo signaling controls cell cycle and restricts cell plasticity in planarians

Nídia de Sousa, Gustavo Rodríguez-Esteban, Jose Ignacio Rojo-Laguna, Emili Saló, Teresa Adell

Neurotransmitter-mediated activity spatially controls neuronal migration in the zebrafish cerebellum

Ulrike Theisen, Christian Hennig, Tobias Ring, Ralf Schnabel, Reinhard W. Köster

Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1

Dino Dvorak, Basma Radwan, Fraser T. Sparks, Zoe Nicole Talbot, André A. Fenton

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

Muhammad S. Alam, Matthias M. Gaida, Subrata Debnath, Harichandra D. Tagad, Lisa M. Miller Jenkins, Ettore Appella, M. Jubayer Rahman, Jonathan D. Ashwell

Evolution of mitotic spindle behavior during the first asymmetric embryonic division of nematodes

Aurore-Cécile Valfort, Caroline Launay, Marie Sémon, Marie Delattre

Identification of osmoadaptive strategies in the halophile, heterotrophic ciliate Schmidingerothrix salinarum

Lea Weinisch, Steffen Kühner, Robin Roth, Maria Grimm, Tamara Roth, Daili J. A. Netz, Antonio J. Pierik, Sabine Filker

Related Articles

  1. With a pinch of extra salt—Did predatory protists steal genes from their food?

Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval

Jennifer Hirst, Daniel N. Itzhak, Robin Antrobus, Georg H. H. Borner, Margaret S. Robinson

Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials

Xinming Yang, Mohamad Koohi-Moghadam, Runming Wang, Yuen-Yan Chang, Patrick C. Y. Woo, Junwen Wang, Hongyan Li, Hongzhe Sun

Short Reports

Mitochondria are physiologically maintained at close to 50 °C

Dominique Chrétien, Paule Bénit, Hyung-Ho Ha, Susanne Keipert, Riyad El-Khoury, Young-Tae Chang, Martin Jastroch, Howard T. Jacobs, Pierre Rustin, Malgorzata Rak

Related Articles

  1. Hot mitochondria?

“Pomacytosis”—Semi-extracellular phagocytosis of cyanobacteria by the smallest marine algae

Nina A. Kamennaya, Gabrielle Kennaway, Bernhard M. Fuchs, Mikhail V. Zubkov

Methods and Resources

An atlas of Caenorhabditis elegans chemoreceptor expression

Berta Vidal, Ulkar Aghayeva, Haosheng Sun, Chen Wang, Lori Glenwinkel, Emily A. Bayer, Oliver Hobert