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Table of Contents: June 2016

Although cellulose is the most abundant terrestrial source of carbon, few organisms have evolved the ability to break it down. Adam J Book et al. investigate the diversity and evolution of cellulolytic ability in the ubiquitous bacterial genus Streptomyces, finding that high cellulolytic ability evolved in select lineages through key changes in gene content and transcriptional regulation. This image shows leaf-cutter ants (Atta cephalotes), one of the many eukaryotic host species found to harbor cellulolytic Streptomyces.

Image Credit: Don Parsons

Perspectives

Border Security Fencing and Wildlife: The End of the Transboundary Paradigm in Eurasia?

John D. C. Linnell, Arie Trouwborst, Luigi Boitani, Petra Kaczensky, Djuro Huber, Slaven Reljic, Josip Kusak, Aleksandra Majic, Tomaz Skrbinsek, Hubert Potocnik, Matt W. Hayward, E. J. Milner-Gulland, Bayarbaatar Buuveibaatar, Kirk A. Olson, Lkhagvasuren Badamjav, Richard Bischof, Steffen Zuther, Urs Breitenmoser

Community Pages

From Static to Interactive: Transforming Data Visualization to Improve Transparency

Tracey L. Weissgerber, Vesna D. Garovic, Marko Savic, Stacey J. Winham, Natasa M. Milic

Research Articles

Indirect Fitness Benefits Enable the Spread of Host Genes Promoting Costly Transfer of Beneficial Plasmids

Tatiana Dimitriu, Dusan Misevic, Chantal Lotton, Sam P. Brown, Ariel B. Lindner, François Taddei

Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression

Adam J. Book, Gina R. Lewin, Bradon R. McDonald, Taichi E. Takasuka, Evelyn Wendt-Pienkowski, Drew T. Doering, Steven Suh, Kenneth F. Raffa, Brian G. Fox, Cameron R. Currie

Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network

Tianwen Chen, Weidong Cai, Srikanth Ryali, Kaustubh Supekar, Vinod Menon

Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light

Violetta Pilorz, Shu K. E. Tam, Steven Hughes, Carina A. Pothecary, Aarti Jagannath, Mark W. Hankins, David M. Bannerman, Stafford L. Lightman, Vladyslav V. Vyazovskiy, Patrick M. Nolan, Russell G. Foster, Stuart N. Peirson

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche

Alistair J. Langlands, Axel A. Almet, Paul L. Appleton, Ian P. Newton, James M. Osborne, Inke S. Näthke

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

Alba Diz-Muñoz, Kevin Thurley, Sana Chintamen, Steven J. Altschuler, Lani F. Wu, Daniel A. Fletcher, Orion D. Weiner

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase

Shuangxi Li, Shuang Li, Yuhong Han, Chao Tong, Bing Wang, Yongbin Chen, Jin Jiang

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

Yousuf O. Ali, Hunter M. Allen, Lei Yu, David Li-Kroeger, Dena Bakhshizadehmahmoudi, Asante Hatcher, Cristin McCabe, Jishu Xu, Nicole Bjorklund, Giulio Taglialatela, David A. Bennett, Philip L. De Jager, Joshua M. Shulman, Hugo J. Bellen, Hui-Chen Lu

The DEAD-box Protein Rok1 Orchestrates 40S and 60S Ribosome Assembly by Promoting the Release of Rrp5 from Pre-40S Ribosomes to Allow for 60S Maturation

Sohail Khoshnevis, Isabel Askenasy, Matthew C. Johnson, Maria D. Dattolo, Crystal L. Young-Erdos, M. Elizabeth Stroupe, Katrin Karbstein

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore

Robin Wray, Irene Iscla, Ya Gao, Hua Li, Junmei Wang, Paul Blount