Submit Now

PLOS Biology authors can now take advantage of the benefits of Aperta™, PLOS’ innovative submission system. Please refer to the submission checklist to get started.


Submit your manuscript to PLOS Biology in
Microsoft Word or PDF formats.

See our Aperta help guides.

Editorial Manager

This system should only be used to edit or revise an existing submission made via Editorial Manager. 



Meet Aperta: A Submission System Built for You

PLOS designed Aperta with researchers in mind. Submission tasks are easy to complete with minimum time demands. Reviewers and Editors can work more efficiently, bringing research online faster.

  • Efficient. Aperta is designed to use modern technology and web design to enable you to easily complete common submission tasks.
  • Flexible. Aperta allows you to complete tasks in any order, and to pause at any point. As Aperta evolves, you and your colleagues will discover enhanced collaboration tools to facilitate more productive interactions with reviewers and community members. 
  • Dynamic. Aperta is designed for continuous improvement. PLOS wants to hear your feedback as we add new features and functionality. Beginning with PLOS Biology, all PLOS publications will move to use Aperta. 
  • Open. PLOS is committed to sharing Aperta with the scientific publishing community to advance Open Access and Open Science. Through our commitment to Open, you and your work can flourish. 

Submission Checklist

Editorial and publishing policies Understand the requirements that apply to your submission, including the policies related to data availability, competing interests, disclosure of funding sources, authorship, and reporting standards.  

Formatting instructions

Review the submission guidelines for information about manuscript style and format.

Guidelines for other article types

See our guidelines if you are submitting content other than a research article.

License agreement

PLOS applies the Creative Commons Attribution (CC BY) license to works we publish. Under this license, authors agree to make articles legally available for reuse, without permission or fees, for virtually any purpose. Anyone may copy, distribute or reuse these articles as long as the authors and original source are properly cited. Read our licenses and copyright policy

Publication fees

Publication fees are US$2,900 per manuscript and will be billed upon acceptance. The ability to pay publication fees is never a consideration in the publication decision process. Read more about publication fees and publication fee support.

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