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About the Aperta Submission System

Submit your next manuscript to PLOS Biology in our Aperta™ submission system.


Aperta offers a refreshing look and feel, with a unique and clean user experience. Our focus is on providing a fast-paced service. The initial submission process requires only your manuscript file along with minimal additional information. 


Aperta also offers flexibility and choice. You can:

  • Submit your manuscript in PDF or Microsoft Word. Aperta will automatically position your figures within uploaded Word files.
  • Preview your manuscript in the browser or download a compiled PDF to your computer.
  • Complete tasks in your preferred order and pause your work to return to it later.

Learn more about Aperta
Take a video tour of the system and its features.
Read our announcement on the PLOS Biology blog, Biologue.
"This was an extremely helpful and efficient means of submitting a paper."
PLOS Biology author Gillian Bates, University College London

How to Submit

To start a submission to PLOS Biology, you only need to provide your manuscript, cover letter, figures, and supporting information files. You will provide additional details and files only if the editors decide that the manuscript is suitable for peer review.


Submit now

This streamlined submission process allows you to quickly send your work to the journal and obtain rapid feedback from the editors without having to prepare all of your materials up front. If the editors decide that the manuscript is suitable for peer review, they will ask you to provide additional information. Read more about the editorial and peer review process.

  See step-by-step instructions for submitting your manuscript in Aperta. 

Author Resources

Consult these resources to make sure that your manuscript is ready for submission and find out what to expect later on in the editorial assessment and peer review process.

Submission guidelines Information about the article types available for primary research and guidelines for manuscript style and formatting
Editorial and publishing policies Information about the requirements that apply to our submissions, including policies on data availability, competing interests, disclosure of funding sources, authorship, and reporting standards.
Other article types Information about preparing submissions to the PLOS Biology magazine.
Revision guidelines Information about preparing a revised submission.
Publication fees Information about publication fees and fee assistance options. Publication fees are US$2900 per manuscript and will be billed upon acceptance. An author’s ability to pay publication fees is never a consideration in the publication decision process.
Looking for Editorial Manager?
PLOS Biology began transitioning to Aperta in May 2016 and no longer accepts new submissions in the Editorial Manager system. If you have any questions about either Editorial Manager or Aperta, please contact

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