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Table of Contents

November 2003

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The nematode C.briggsae.
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A high quality sequence of the Caenorhabditis briggsae genome is now in hand. Comparisons with the C. elegans genome sequence provide valuable insights into the processes that have shaped the evolution of these organisms, which diverged 80-110 million years ago. The new sequence also gives C. elegans biologists a powerful new tool to refine their knowledge of gene identity and function in C. elegans. (See Stein, et al.)

Image Credit: Photo provided by David H. A. Fitch, New York University. Additional photo manipulation by John Heisch, John Heisch Design

Editorial

The What and Whys of DOIs

Susanne DeRisi, Rebecca Kennison, Nick Twyman

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000057

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Essay

Genomics Research and Malaria Control: Great Expectations

Vincent P Alibu, Thomas G Egwang

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000039

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Features

Tough Mining

Steven Dickman

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000048

Beyond the Fire-Hazard Mentality of Medicine: The Ecology of Infectious Diseases

Jane Bradbury

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000022

Obituary

Patricia Goldman-Rakic

Pat Levitt

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000038

Journal Club

Army Ants Trapped by Their Evolutionary History

Frédéric Delsuc

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000037

Primers

Comparative Genomics

Ross C Hardison

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000058

Current Approaches to the Study of Movement Control

Alla Katsnelson

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000050

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Community Page

Biodiversity Conservation Demands Open Access

Gustavo Fonseca, Philippa J Benson

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000046

Research Articles

The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics

Lincoln D Stein, Zhirong Bao, Darin Blasiar, Thomas Blumenthal, Michael R Brent, Nansheng Chen, Asif Chinwalla, Laura Clarke, Chris Clee, Avril Coghlan, Alan Coulson, Peter D'Eustachio, David H. A Fitch, Lucinda A Fulton, Robert E Fulton, Sam Griffiths-Jones, Todd W Harris, LaDeana W Hillier, Ravi Kamath, Patricia E Kuwabara, Elaine R Mardis, Marco A Marra, Tracie L Miner, Patrick Minx, James C Mullikin, Robert W Plumb, Jane Rogers, Jacqueline E Schein, Marc Sohrmann, John Spieth, Jason E Stajich, Chaochun Wei, David Willey, Richard K Wilson, Richard Durbin, Robert H Waterston

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000045

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Learning to Control a Brain–Machine Interface for Reaching and Grasping by Primates

Jose M Carmena, Mikhail A Lebedev, Roy E Crist, Joseph E O'Doherty, David M Santucci, Dragan F Dimitrov, Parag G Patil, Craig S Henriquez, Miguel A. L Nicolelis

PLOS Biology: published October 13, 2003 | https://doi.org/10.1371/journal.pbio.0000042

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A Gain-Field Encoding of Limb Position and Velocity in the Internal Model of Arm Dynamics

Eun Jung Hwang, Opher Donchin, Maurice A Smith, Reza Shadmehr

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000025

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Embryonic Origins of a Motor System: Motor Dendrites Form a Myotopic Map in Drosophila

Matthias Landgraf, Victoria Jeffrey, Miki Fujioka, James B Jaynes, Michael Bate

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000041

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Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA

Viola Ellison, Bruce Stillman

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000033

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The Drosophila Sterile-20 Kinase Slik Controls Cell Proliferation and Apoptosis during Imaginal Disc Development

David R Hipfner, Stephen M Cohen

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000035

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  1. slik Gene Controls Cell Growth and Survival

Viral Discovery and Sequence Recovery Using DNA Microarrays

David Wang, Anatoly Urisman, Yu-Tsueng Liu, Michael Springer, Thomas G Ksiazek, Dean D Erdman, Elaine R Mardis, Matthew Hickenbotham, Vincent Magrini, James Eldred, J. Phillipe Latreille, Richard K Wilson, Don Ganem, Joseph L DeRisi

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000002

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  1. Gene Chip for Viral Discovery

Partially Phosphorylated Pho4 Activates Transcription of a Subset of Phosphate-Responsive Genes

Michael Springer, Dennis D Wykoff, Nicole Miller, Erin K O'Shea

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000028

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T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression

Jeroen P Roose, Maximilian Diehn, Michael G Tomlinson, Joseph Lin, Ash A Alizadeh, David Botstein, Patrick O Brown, Arthur Weiss

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000053

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Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development

Michelle D Tallquist, Wendy J French, Philippe Soriano

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000052

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Book Review%2FScience in the Media

A Field Trip to the Mesozoic

Luis M Chiappe

PLOS Biology: published November 17, 2003 | https://doi.org/10.1371/journal.pbio.0000040