Figures
Dramatic separation of the centrosomes and the nucleus in dynein-depleted human cells at the onset of mitosis.
A cell depleted of the dynein-heavy chain and stained for microtubules (green), centrosomes (red), and DNA (blue). Dynein activity at the nuclear envelope keeps the centrosomes closely tethered to the nucleus during mitotic entry. In the absence of dynein, centrosomes and the nucleus are actively displaced to opposite sides of the cell as a result of the antagonistic activity of kinesin-1, pushing the centrosomes and the nucleus apart (see Splinter et al., e1000350).
Image Credit: Marvin Tanenbaum, Department of Medical Oncology and Cancer Genomics Center, University Medical Center, Utrecht, The Netherlands
Citation: (2010) PLoS Biology Issue Image | Vol. 8(4) April 2010. PLoS Biol 8(4): ev08.i04. https://doi.org/10.1371/image.pbio.v08.i04
Published: April 27, 2010
Copyright: © 2010 Splinter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A cell depleted of the dynein-heavy chain and stained for microtubules (green), centrosomes (red), and DNA (blue). Dynein activity at the nuclear envelope keeps the centrosomes closely tethered to the nucleus during mitotic entry. In the absence of dynein, centrosomes and the nucleus are actively displaced to opposite sides of the cell as a result of the antagonistic activity of kinesin-1, pushing the centrosomes and the nucleus apart (see Splinter et al., e1000350).
Image Credit: Marvin Tanenbaum, Department of Medical Oncology and Cancer Genomics Center, University Medical Center, Utrecht, The Netherlands