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Structural basis for human DPP4 receptor recognition by a pangolin MERS-like coronavirus
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Mo Yang, Zehou Li, Jing Chen, Yang Li, Ran Xu, Meihua Wang, Ying Xu, Rong Chen, Weiwei Ji, Xiaoxia Li, Jiayu Wei, Zhengrong Zhou, Minjie Ren, Ke Ma, Jiayu Guan, Guoxiang Mo, Peng Zhou, Bo Shu, Jingjing Guo, Yuan Yuan, Zheng-Li Shi, Shuijun Zhang
Research Article |
published 08 Nov 2024
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1012695
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Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean–Congo hemorrhagic fever virus
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Liushuai Li, Tingting Chong, Lu Peng, Yajie Liu, Guibo Rao, Yan Fu, Yanni Shu, Jiamei Shen, Qinghong Xiao, Jia Liu, Jiang Li, Fei Deng, Bing Yan, Zhihong Hu, Sheng Cao, Manli Wang
Research Article |
published 01 Feb 2024
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1011948
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Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses
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Hua Chen, Sheng Lin, Fanli Yang, Zimin Chen, Liyan Guo, Jing Yang, Xi Lin, Lingling Wang, Yanping Duan, Ao Wen, Xindan Zhang, Yushan Dai, Keqing Yin, Xin Yuan, Chongzhang Yu, Yarong He, Bin He, Yu Cao, Haohao Dong, Jian Li, Qi Zhao, Quan Liu, Guangwen Lu
Research Article |
published 13 Oct 2023
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1011694
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Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope
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Keisuke Tonouchi, Yu Adachi, Tateki Suzuki, Daisuke Kuroda, Ayae Nishiyama, Kohei Yumoto, Haruko Takeyama, Tadaki Suzuki, Takao Hashiguchi, Yoshimasa Takahashi
Research Article |
published 09 Aug 2023
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1011554
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Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals
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Jithesh Kottur, Kris M. White, M. Luis Rodriguez, Olga Rechkoblit, Richard Quintana-Feliciano, Ahana Nayar, Adolfo García-Sastre, Aneel K. Aggarwal
Research Article |
published 31 Jul 2023
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1011546
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Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range
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Dongchun Ni, Priscilla Turelli, Bertrand Beckert, Sergey Nazarov, Emiko Uchikawa, Alexander Myasnikov, Florence Pojer, Didier Trono, Henning Stahlberg, Kelvin Lau
Research Article |
published 05 Apr 2023
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1011206
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Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA
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Sai Sundar Rajan Raghavan, Robert Dagil, Mary Lopez-Perez, Julian Conrad, Maria Rosaria Bassi, Maria del Pilar Quintana, Swati Choudhary, Tobias Gustavsson, Yong Wang, Pontus Gourdon, Michael Fokuo Ofori, Sebastian Boje Christensen, Daniel Thomas Remias Minja, Christentze Schmiegelow, Morten Agertoug Nielsen, Lea Barfod, Lars Hviid, Ali Salanti, Thomas Lavstsen, Kaituo Wang
Research Article |
published 16 Nov 2022
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1010924
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In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding
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Neil Bate, Christos G. Savva, Peter C. E. Moody, Edward A. Brown, Sian E. Evans, Jonathan K. Ball, John W. R. Schwabe, Julian E. Sale, Nicholas P. J. Brindle
Research Article |
published 18 Jul 2022
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1010733
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A single amino acid polymorphism in a conserved effector of the multihost blast fungus pathogen expands host-target binding spectrum
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Adam R. Bentham, Yohann Petit-Houdenot, Joe Win, Izumi Chuma, Ryohei Terauchi, Mark J. Banfield, Sophien Kamoun, Thorsten Langner
Research Article |
published 10 Nov 2021
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1009957
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The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface
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Juan Carlos De la Concepcion, Josephine H. R. Maidment, Apinya Longya, Gui Xiao, Marina Franceschetti, Mark J. Banfield
Research Article |
published 01 Mar 2021
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1009368
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NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings
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Chenxi Li, Di Di, Hui Huang, Xin Wang, Qiqi Xia, Xiaochun Ma, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Zongjie Li, Jianchao Wei, Zhiyong Ma
Research Article |
published 03 Sep 2020
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1008773
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Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein
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David Oyen, Jonathan L. Torres, Phillip C. Aoto, Yevel Flores-Garcia, Špela Binter, Tossapol Pholcharee, Sean Carroll, Sini Reponen, Rachael Wash, Qi Liang, Franck Lemiale, Emily Locke, Allan Bradley, C. Richter King, Daniel Emerling, Paul Kellam, Fidel Zavala, Andrew B. Ward, Ian A. Wilson
Research Article |
published 09 Mar 2020
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1008373
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Cryo-EM structure of the Shigella type III needle complex
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Michele Lunelli, Antje Kamprad, Jörg Bürger, Thorsten Mielke, Christian M. T. Spahn, Michael Kolbe
Research Article |
published 24 Feb 2020
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1008263
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Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents
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Sergei Perov, Ofir Lidor, Nir Salinas, Nimrod Golan, Einav Tayeb- Fligelman, Maya Deshmukh, Dieter Willbold, Meytal Landau
Research Article |
published 30 Aug 2019
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1007978
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Alternative conformations of a major antigenic site on RSV F
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Harrison G. Jones, Michael B. Battles, Chun-Chi Lin, Siro Bianchi, Davide Corti, Jason S. McLellan
Research Article |
published 15 Jul 2019
PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1007944