A Major Role for the Plasmodium falciparum ApiAP2 Protein PfSIP2 in Chromosome End Biology
Figure 6
Overexpression of PfSIP2-N-HA has no effect on global gene transcription.
Global transcript profiles in 3D7/SIP2-N-HA parasites were compared to the control line 3D7/camHG [27] at four timepoints across the IDC. TP1: ring stages 4–14 hours post-invasion (hpi); TP2: late ring stages 14–24 hpi; TP3: trophozoites 24–34 hpi; TP4: schizonts 32–42 hpi. All genes transcribed at greater 3-fold difference in 3D7/SIP2-N-HA compared to the control in at least one timepoint are listed. Over-expression of pfsip2-n is shown on top. The heat map indicates fold differences in transcript abundance on a gradual scale (green: down-regulated; red: up-regulated). Gene annotations are listed to the right and are according to PlasmoDB version5.5 (www.plasmodb.org).
