The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes

Nicholas M. Kanaan; Timothy J. Collier; Allyson Cole-Strauss; Tessa Grabinski; Zachary R. Mattingly; Mary E. Winn; Kathy Steece-Collier; Caryl E. Sortwell; Fredric P. Manfredsson; Jack W. Lipton

doi:10.1371/journal.pone.0127768

Open Access

Peer-reviewed

Research Article

The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes

Nicholas M. Kanaan ,

Contributed equally to this work with: Nicholas M. Kanaan, Timothy J. Collier

Affiliations Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America, Morris. K. Udall Center of Excellence in Parkinson’s Disease Research, Michigan State University, Grand Rapids, MI, United States of America, Hauenstein Neuroscience Center, Mercy Health Saint Mary’s, Grand Rapids, Michigan, United States of America
⨯
Timothy J. Collier ,

Contributed equally to this work with: Nicholas M. Kanaan, Timothy J. Collier

Affiliations Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America, Morris. K. Udall Center of Excellence in Parkinson’s Disease Research, Michigan State University, Grand Rapids, MI, United States of America, Hauenstein Neuroscience Center, Mercy Health Saint Mary’s, Grand Rapids, Michigan, United States of America
⨯
Allyson Cole-Strauss,

Affiliations Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America, Morris. K. Udall Center of Excellence in Parkinson’s Disease Research, Michigan State University, Grand Rapids, MI, United States of America
⨯
Tessa Grabinski,

Affiliation Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America
⨯
Zachary R. Mattingly,

Affiliation Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America
⨯
Mary E. Winn,

Affiliation Bioinformatics & Biostatistics Core, Van Andel Research Institute, Grand Rapids, MI, United States of America
⨯
Kathy Steece-Collier,

Affiliations Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America, Morris. K. Udall Center of Excellence in Parkinson’s Disease Research, Michigan State University, Grand Rapids, MI, United States of America, Hauenstein Neuroscience Center, Mercy Health Saint Mary’s, Grand Rapids, Michigan, United States of America
⨯
Caryl E. Sortwell,

Affiliations Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America, Morris. K. Udall Center of Excellence in Parkinson’s Disease Research, Michigan State University, Grand Rapids, MI, United States of America, Hauenstein Neuroscience Center, Mercy Health Saint Mary’s, Grand Rapids, Michigan, United States of America
⨯
Fredric P. Manfredsson,

Affiliation Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America
⨯
Jack W. Lipton

* E-mail: jack.lipton@hc.msu.edu

Affiliations Department of Translational Science & Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America, Morris. K. Udall Center of Excellence in Parkinson’s Disease Research, Michigan State University, Grand Rapids, MI, United States of America, Hauenstein Neuroscience Center, Mercy Health Saint Mary’s, Grand Rapids, Michigan, United States of America
⨯

The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes

Nicholas M. Kanaan, …
Timothy J. Collier,
Allyson Cole-Strauss,
Tessa Grabinski,
Zachary R. Mattingly,
Mary E. Winn,
Kathy Steece-Collier,
Caryl E. Sortwell,
Fredric P. Manfredsson,
Jack W. Lipton

x

Published: May 20, 2015
https://doi.org/10.1371/journal.pone.0127768

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