Supplemetation of β-carotene alters body adiposity in wild-type mice.
(A) Effects of dietary β-carotene supplementation on body weight gain, (B) cumulative energy intake, (C) energy efficiency, (D) adiposity index, (E) adipose depot weight, and (F) inguinal adipocyte mean sectional area, in wild-type (WT) and Bcmo1-null (Bcmo1-/-) mice. In (G), micrographs of sections of inguinal fat in the four groups are shown (The scale bar gives 100 µm). Data in (A to E) are the mean±SEM of 6 animals per group, and data in (F) of 3 animals per group Open bars, animals on the control diet; black bars, animals on the β-carotene-enriched diet. Body weight gain, cumulative energy intake and energy efficiency over the entire 14 week experimental period are shown. Adiposity index corresponds to the sum of all entirely dissected white adipose tissue depots (gonadal, Gon; inguinal, Ing; and retroperitoneal, Retr), expressed as percentage of the animal body weight (BW).. G, genotype effect in two-way ANOVA analysis (p<0.05); D, effect of diet in two-way ANOVA analysis (p<0.05);*, p<0.05 in Student's t test, BC diet versus control diet.