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Gap Junctional Communication in Osteocytes Is Amplified by Low Intensity Vibrations In Vitro

Figure 4

Vibration induced GJIC is controlled by Akt signaling.

One hour after vibration treatment, (A) Cx43 mRNA levels remained unchanged. (B) Cx43 protein levels were also unaffected by vibrations (0.15 gā€“100 Hz) without and with Akt inhibition but (C) vibrations increased Akt phosphorylation (ser 473) 2.4-fold. (D) Inhibition of Akt activation also inhibited the vibration induced increase in calcein transference. ***: p<0.001 against control.

Figure 4