Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome
Fig 3
Protein content of α7 and proteasome activators in WT and L7M1 mice with denervation.
(A-C) Results of densitometry are presented as the fold change compared to WT 0 Day for each respective protein. Each panel contains results of two-way ANOVA that were used to detect the effect of strain (WT vs. L7M1) and time (Day 0, 7, and 14) for (A) α7, (B) PA700/ Rpt1, and (C) PA28α (# indicates significant effect of strain/time/S x T interactions, p < .05). Statistical comparison showed a significant denervation (time) effect in all the proteins (p < .001). No strain effect was detected in any of these proteins. Values are mean ± SE. Sample size per group: n = 7–10. Representative Western blot for each protein is presented in Fig 1.
