Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice
Fig 2
Histological analysis of LV and septal myocardium after TAC.
Significant cardiomyocyte hypertrophy (A) and interstitial fibrosis (B) were induced by TAC, whereas the density of endocardial capillaries was mildly decreased (C). (D) Infiltration of CD45 positive leukocytes was apparent after TAC, although this did not reach statistical significance in Malat-1 KO mice. Importantly, no significant differences could be detected between Malat-1 WT and KO mice for any of the histological parameters. *p<0.05, **p<0.01 TAC versus Sham. Scale bars: Sirius Red: 1 mm; all other stains: 100 μm.
