Consistency Analysis of Genome-Scale Models of Bacterial Metabolism: A Metamodel Approach
Fig 3
Three examples of pathways unblocked as a consequences of the metamodel construction.
In a) a partial representation of the aerobic degradation of catechol is depicted (metabolites in circles were manually added to clarify the diagram). In b) the import of choline sulfate is shown as an example of an in-to-out linear pathway artifact. In c) an example of an artifact is shown, with a set of reactions corresponding to two different variants of the adenosylcobalamin biosynthetic pathway: early cobalt insertion (right side); late cobalt incorporation (left side). Cofactors and currency metabolites were excluded from this representation. Metabolite abbreviations can be found in S3C Table.
