Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells
Fig 4
Branch point analysis across the human metabolic protein network.
(a) Diagram clarifying method for computing various Branch Divergence scores in 2 different circumstances. Orange squares indicate reactant and product metabolites with blue ovals indicating the reacting enzymes. (b) Histogram of Branch Divergence Scores based on top 2 values. Each bin is lower end inclusive with a bin size of 0.1. (c) Histogram of Branch Divergence Scores based on top 3 values. Each bin is lower end inclusive with a bin size of 0.1. (d) Plot indicating the p-values for pathways that have significantly different counts in one-sided and equally distributed pathways (defined as a p-value < 0.05). (e) Ratio of one-sided counts to equally distributed counts for significant pathways.
