Monitoring Brain Tumor Vascular Heamodynamic following Anti-Angiogenic Therapy with Advanced Magnetic Resonance Imaging in Mice
Figure 4
Glioblastoma imaging parameters progression over time.
(A) Serial coronal FISP (first row) and T2W (second row) images of a control tumor that were acquired on days 7, 14, 18 and 22. The corresponding DWI (third row) and HRI (fourth row) maps are also shown. ROIs delineating the tumor and contra-lateral healthy brain tissue are marked on the FISP and T2W images (blue line). Increased HRI response during tumor progression can be seen both in the HRI maps and in the ROI-time-course (RTC) graphs (fifth row). The average diffusion values (B) and the HRI values (C) of the tumors (blue) and the contra-lateral side (CLS; red) are given as a function of time from cell inoculation. Note that the diffusion values are higher than the CLS throughout the entire period while tumor HRI increased over time. ***denotes statistical significance at P<0.005 compared to the CLS value.
