Single Nucleotide Polymorphism Network: A Combinatorial Paradigm for Risk Prediction
Figure 7
Network representation of segregation of combined genotypic data of three population (oral cancer, leukoplakia and control).
Five SNPs (studied with leukoplakia, cancer and control samples) of each individual are combined to form super-set genotypes. One hundred fourty three unique genotype-sets are observed of which 18 are specific to each control, leukoplakia and cancer individuals, 12 genotype-sets are present in both control and leukoplakia individuals, 18 genotype-sets are present in both control and cancer individuals, only 6 genotype-sets are common between leukoplakia and cancer individuals and as many as 53 genotype-sets are common to case, control and leukoplakia. The number of occurrences of each particular genotype-set is illustrated through its corresponding edge-width.
The circles in i) red ii) violet iii) yellow iv) prussian blue v) grey vi) orange and vii) blue respectively represents the following groups i) cancer only ii) cancer and control iii) leukoplakia only iv) control only v) control and leukoplakia vi) cancer and leukoplakia and vii) cancer, leukoplakia and control.
