The Role of Mislocalized Phototransduction in Photoreceptor Cell Death of Retinitis Pigmentosa
Figure 7
SQ22536 treatment of rd10 mice.
(A and B) HE (Hematoxilin-Eosin) stained sections from eyes of rd10 mice at P28. Control PBS treated eye (A) and SQ22536 treated eye (B). OS: outer segment, IS: inner segment, ONL: outer nuclear layer (Bar = 10 µm.). (C) Graph of the thickness of INL (outlined bar) and ONL (solid bar) in rd10 mice at P28. Control group (black) and SQ treated group (red) are compared. (Bars mean SD, * means p<0.05.) (D) Graph of the ONL/INL ratio of SQ22536 treated control (black bar) and untreated retina (red bar) in rd10 mice. (E) Schematic illustration of adenylyl cyclase and apoptosis in rod photoreceptors. OS: outer segment, CC: connecting cilium, IS: inner segment, R: rhodopsin, T: transducin, AC: adenylyl cyclase.
