About the Authors

Elizabeth P. Darga

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Emily M. Dolce

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Fang Fang

Roles Data curation, Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

Kelley M. Kidwell

Roles Data curation, Formal analysis, Methodology, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliations University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

Christina L. Gersch

Roles Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Steven Kregel

Roles Investigation, Methodology, Resources, Writing – review & editing

Affiliations University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America, Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

Dafydd G. Thomas

Roles Investigation, Resources, Writing – review & editing

Affiliation University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Anoop Gill

Roles Resources, Writing – review & editing

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Martha E. Brown

Roles Resources, Writing – review & editing

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Steven Gross

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Menarini Silicon Biosystems, Huntingdon Valley, Pennsylvania, United States of America

Mark Connelly

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Menarini Silicon Biosystems, Huntingdon Valley, Pennsylvania, United States of America

Michael Holinstat

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliation Departments of Pharmacology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Erin F. Cobain

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

James M. Rae

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America, Departments of Pharmacology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Daniel F. Hayes

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

hayesdf@umich.edu

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Costanza Paoletti

Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Current address: EISAI Inc., Woodcliff Lake, New Jersey, United States of America

Affiliations Breast Oncology Program, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: C.P. reports non-financial support (travel paid), contracts, and research support from Menarini Silicon Biosystems (MSB), the manufacturer of CellSearch® and, outside the submitted work, research funding from AstraZeneca, and Pfizer. C.P. is currently an employee of Eisai, Inc. University of Michigan (UM) has received funding to support research on behalf of D.F.H. and from Menarini/Silicon Biosystems, manufacturer of CellSearch. UM has submitted a patent application related to CTC and platelet PDL1 testing on which D.F.H., C.P., E.P.D. and E.M.D. are named inventors/co-inventors.UM holds patent US 8,790,878 B2 for which D.F.H. is designated as inventor, and that is licensed to MSB with annual royalties through January 2021. Outside the submitted work D.F.H. holds stock options from InBiomotion, and serves on advisory boards for Cepheid, Freenome, CellWorks, Lexent Bio, EPIC Science, Salutogenic Innovations, L-Nutra, BioVeca, OncoCyte, Turnstone Biologics, Predictus BioSciences, Tempus, Guardant and UM has received funding to support research on behalf of D.F.H. from Astra Zeneca, Merrimack, Eli Lilly, Puma Biotechnology, Pfizer. Outside the submitted work M.H. serves as a consultant and receives research support from Veralox Therapeutics. Outside the submitted work E.F.C. has served advisory/consulting roles for AstraZeneca, Biotheranostics, Ayala Pharmaceuticals and Athenex Oncology. The remaining co-authors have declared that no competing interests exist.