About the Authors

Yun Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America

Kelvin Zhang

Roles Data curation, Investigation, Methodology, Software, Writing – original draft

Current address: Codiak BioSciences, Cambridge, Massachusetts, United States of America

Affiliation Department of Genetics and Pharmacogenomics, Merck & Co., Inc., Boston, Massachusetts, United States of America

Peter Georgiev

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America

Steven Wells

Roles Data curation, Investigation, Methodology

Current address: Columbia University, New York City, New York, United States of America

Affiliation Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America

Haiyan Xu

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America

Brian M. Lacey

Roles Data curation, Investigation

Affiliation Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America

Zangwei Xu

Roles Data curation, Investigation

Affiliation Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America

Jason Laskey

Roles Data curation, Investigation

Affiliation Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America

Robbie Mcleod

Roles Conceptualization

Affiliation Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America

Joey L. Methot

Roles Conceptualization, Data curation, Investigation

Affiliation Department of Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, United States of America

Mark Bittinger

Roles Conceptualization

Current address: Sai Life Sciences Inc., Cambridge, Massachusetts, United States of America

Affiliation Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America

Alexander Pasternak

Roles Conceptualization, Writing – review & editing

alexander_pasternak@merck.com (AP); sheila.ranganath@merck.com (SR)

Affiliation Department of Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, United States of America

Sheila Ranganath

Roles Conceptualization, Writing – review & editing

alexander_pasternak@merck.com (AP); sheila.ranganath@merck.com (SR)

Affiliation Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America

Competing Interests

No authors have competing interests and the commercial affiliation with Merck & Co Inc does not alter our adherence to PLOS ONE policies on sharing data and materials.