About the Authors

Joshua A. Stern

Affiliation Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

Svetlana Markova

Affiliation MyoKardia, Inc., South San Francisco, California, United States of America

Yu Ueda

Affiliation Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

Jae B. Kim

Current address: Alnylam Pharmaceuticals, Cambridge, Massachusetts, United States of America

Affiliation MyoKardia, Inc., South San Francisco, California, United States of America

Peter J. Pascoe

Affiliation Department of Surgical & Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

Marc J. Evanchik

Affiliation MyoKardia, Inc., South San Francisco, California, United States of America

Eric M. Green

samharris@email.arizona.edu (SPH); egreen@myokardia.com (EMG)

‡ Joint Senior Authors.

Affiliation MyoKardia, Inc., South San Francisco, California, United States of America

Samantha P. Harris

samharris@email.arizona.edu (SPH); egreen@myokardia.com (EMG)

‡ Joint Senior Authors.

Affiliation Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America

Competing Interests

This work was supported in part by an unrestricted research grant from MyoKardia, Inc. to SPH, SM, MJE and EMG are employees and own shares of, and JBK is a former employee and owns shares of, MyoKardia, Inc., a biotechnology company developing small molecules that target the sarcomere for treatment of inherited cardiomyopathy. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: JAS EMG SPH. Formal analysis: JAS EMG. Funding acquisition: SPH. Investigation: JAS SM YU EMG SPH. Methodology: JAS SM JBK PJP MJE EMG SPH. Project administration: JAS EMG SPH. Resources: JAS EMG SPH. Supervision: JAS MJE EMG SPH. Visualization: EMG. Writing – original draft: EMG. Writing – review & editing: JAS SM YU JBK PJP MJE EMG SPH.