About the Authors

Ronald K. Blackman

Affiliation Synta Pharmaceuticals Corp., Lexington, Massachusetts, United States of America

Kahlin Cheung-Ong

Affiliation Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, Ontario, Canada

Marinella Gebbia

Affiliation Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, Ontario, Canada

David A. Proia

Affiliation Synta Pharmaceuticals Corp., Lexington, Massachusetts, United States of America

Suqin He

Affiliation Synta Pharmaceuticals Corp., Lexington, Massachusetts, United States of America

Jane Kepros

Affiliation Synta Pharmaceuticals Corp., Lexington, Massachusetts, United States of America

Aurelie Jonneaux

Affiliation UMR 837 – INSERM, Université de Lille II & CHRU LILLE, Lille, France

Philippe Marchetti

Affiliation UMR 837 – INSERM, Université de Lille II & CHRU LILLE, Lille, France

Jerome Kluza

Affiliation UMR 837 – INSERM, Université de Lille II & CHRU LILLE, Lille, France

Patricia E. Rao

Affiliation Synta Pharmaceuticals Corp., Lexington, Massachusetts, United States of America

Yumiko Wada

Affiliation Synta Pharmaceuticals Corp., Lexington, Massachusetts, United States of America

Guri Giaever

Affiliation Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, Ontario, Canada

Corey Nislow

corey.nislow@utoronto.ca

Affiliation Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, Ontario, Canada

Competing Interests

RKB, DAP, SH, J. Kepros, PER and YW are or were employees of Synta Pharmaceuticals, Corp. Elesclomol is a Synta product. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. There are no other competing interests to declare.

Author Contributions

Conceived and designed the experiments: CN RKB DAP PM J. Kluza. Performed the experiments: CN MG KC-O RKB DAP SH J. Kepros AJ. Analyzed the data: RKB CN GG DAP PM J. Kluza PER YW. Wrote the paper: RKB CN.