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Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
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Robert F. Hillary, Daniel L. McCartney, Hannah M. Smith, Elena Bernabeu, Danni A. Gadd, Aleksandra D. Chybowska, Yipeng Cheng, Lee Murphy, Nicola Wrobel, Archie Campbell, Rosie M. Walker, Caroline Hayward, Kathryn L. Evans, Andrew M. McIntosh, Riccardo E. Marioni
Research Article |
published 06 Jul 2023
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1004247
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Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial
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Xinlei Ma, Fan Yang, Jinzhi Wu, Bei Xu, Mengdi Jiang, Yiduo Sun, Chuanying Sun, Ye Yu, Danyi Xu, Lanlan Xiao, Chunyun Ren, Chunyan Chen, Zi Ye, Junyu Liang, Jin Lin, Weiqian Chen
Research Article |
published 29 Jun 2023
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1004249
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Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study
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Si Fang, James Yarmolinsky, Dipender Gill, Caroline J. Bull, Claire M. Perks, the PRACTICAL Consortium , George Davey Smith, Tom R. Gaunt, Tom G. Richardson
Research Article |
published 03 Jan 2023
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003988
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The evolution of mendelian randomization for investigating drug effects
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Dipender Gill, Stephen Burgess
Perspective |
published 03 Feb 2022
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003898
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study
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Vijay R. Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C. Delgado, Anup M. Oommen, Jackson A. Roberts, Dean F. Wong, Christos Davatzikos, Susan M. Resnick, Juan C. Troncoso, Olga Pletnikova, Richard O’Brien, Eelko Hak, Brenda N. Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A. Bennett, Shahinaz M. Gadalla, Madhav Thambisetty
Research Article |
published 27 May 2021
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003615
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Maternal dysglycaemia, changes in the infant’s epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial
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Elie Antoun, Negusse T. Kitaba, Philip Titcombe, Kathryn V. Dalrymple, Emma S. Garratt, Sheila J. Barton, Robert Murray, Paul T. Seed, Joanna D. Holbrook, Michael S. Kobor, David TS Lin, Julia L. MacIsaac, Graham C. Burdge, Sara L. White, Lucilla Poston, Keith M. Godfrey, Karen A. Lillycrop, UPBEAT Consortium
Research Article |
published 05 Nov 2020
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003229
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Mediterranean diet and endothelial function in patients with coronary heart disease: An analysis of the CORDIOPREV randomized controlled trial
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Elena M. Yubero-Serrano, Carolina Fernandez-Gandara, Antonio Garcia-Rios, Oriol A. Rangel-Zuñiga, Francisco M. Gutierrez-Mariscal, Jose D. Torres-Peña, Carmen Marin, Javier Lopez-Moreno, Justo P. Castaño, Javier Delgado-Lista, Jose M. Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda
Research Article |
published 09 Sep 2020
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003282
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Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study
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Uma V. Mahajan, Vijay R. Varma, Michael E. Griswold, Chad T. Blackshear, Yang An, Anup M. Oommen, Sudhir Varma, Juan C. Troncoso, Olga Pletnikova, Richard O’Brien, Timothy J. Hohman, Cristina Legido-Quigley, Madhav Thambisetty
Research Article |
published 24 Jan 2020
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003012
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A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
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Philip T. James, Ousubie Jawla, Nuredin I. Mohammed, Kabiru Ceesay, Fatai M. Akemokwe, Bakary Sonko, Ebrima A. Sise, Andrew M. Prentice, Matt J. Silver
Research Article |
published 13 Aug 2019
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002870
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Validation of the prognostic value of NF-κB p65 in prostate cancer: A retrospective study using a large multi-institutional cohort of the Canadian Prostate Cancer Biomarker Network
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Andrée-Anne Grosset, Véronique Ouellet, Christine Caron, Gabriela Fragoso, Véronique Barrès, Nathalie Delvoye, Mathieu Latour, Armen Aprikian, Alain Bergeron, Simone Chevalier, Ladan Fazli, Neil Fleshner, Martin Gleave, Pierre Karakiewicz, Louis Lacombe, Jean-Baptiste Lattouf, Theodorus van der Kwast, Dominique Trudel, Anne-Marie Mes-Masson, Fred Saad, for the Canadian Prostate Cancer Biomarker Network
Research Article |
published 02 Jul 2019
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002847
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Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures
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Hayley Warsinske, Rohit Vashisht, Purvesh Khatri
Research Article |
published 23 Apr 2019
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002786
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Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study
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Jakob Nikolas Kather, Johannes Krisam, Pornpimol Charoentong, Tom Luedde, Esther Herpel, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Nektarios A. Valous, Dyke Ferber, Lina Jansen, Constantino Carlos Reyes-Aldasoro, Inka Zörnig, Dirk Jäger, Hermann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Niels Halama
Research Article |
published 24 Jan 2019
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002730
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Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts
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Andrew S. P. Lim, Chris Gaiteri, Lei Yu, Shahmir Sohail, Walter Swardfager, Shinya Tasaki, Julie A. Schneider, Claire Paquet, Donald T. Stuss, Mario Masellis, Sandra E. Black, Jacques Hugon, Aron S. Buchman, Lisa L. Barnes, David A. Bennett, Philip L. De Jager
Research Article |
published 04 Sep 2018
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002647
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Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study
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Robert Molokie, Donald Lavelle, Michel Gowhari, Michael Pacini, Lani Krauz, Johara Hassan, Vinzon Ibanez, Maria A. Ruiz, Kwok Peng Ng, Philip Woost, Tomas Radivoyevitch, Daisy Pacelli, Sherry Fada, Matthew Rump, Matthew Hsieh, John F. Tisdale, James Jacobberger, Mitch Phelps, James Douglas Engel, Santhosh Saraf, Lewis L. Hsu, Victor Gordeuk, Joseph DeSimone, Yogen Saunthararajah
Research Article |
published 07 Sep 2017
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002382
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Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study
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Claudia P. Cabrera, Joanna Manson, Joanna M. Shepherd, Hew D. Torrance, David Watson, M. Paula Longhi, Mimoza Hoti, Minal B. Patel, Michael O’Dwyer, Sussan Nourshargh, Daniel J. Pennington, Michael R. Barnes, Karim Brohi
Research Article |
published 17 Jul 2017
PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002352
