Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

• Daouda Sissoko,

  Affiliations Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France

  ⨯
• Cedric Laouenan,

  Affiliations Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France, Assistance Publique–Hôpitaux de Paris, Hôpital Bichat Claude Bernard, Paris, France

  ⨯
• Elin Folkesson,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Abdoul-Bing M’Lebing,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Abdoul-Habib Beavogui,

  Affiliation Centre de Recherche en Santé Rurale, Maférinya, Guinea

  ⨯
• Sylvain Baize,

  Affiliations Institut Pasteur, Centre International de Recherche en Infectiologie, Lyon, France, Inserm, Laboratoire P4 Jean Mérieux, Lyon, France

  ⨯
• Alseny-Modet Camara,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Piet Maes,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Rega Institute for Medical Research, Leuven, Belgium

  ⨯
• Susan Shepherd,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Christine Danel,

  Affiliations Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France, ALIMA, Dakar, Senegal, Programme PACCI, Abidjan, Côte d’Ivoire

  ⨯
• Sara Carazo,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Mamoudou N. Conde,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Jean-Luc Gala,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Cliniques Universitaires Saint-Luc, Brussels, Belgium, Université Catholique de Louvain, Louvain-la-Neuve, Belgium, Belgian Ministry of Defense, Brussels, Belgium

  ⨯
• Géraldine Colin,

  Affiliations Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France, Programme PACCI, Abidjan, Côte d’Ivoire, Croix Rouge Française, Paris, France

  ⨯
• Hélène Savini,

  Affiliation Service de Santé des Armées, Paris, France

  ⨯
• Joseph Akoi Bore,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Institut National de Santé Publique, Conakry, Guinea, Laboratoire des Fièvres Hémorragiques en Guinée, Université Gamal Abdel Nasser de Conakry, Conakry, Guinea

  ⨯
• Frederic Le Marcis,

  Affiliation Ecole Normale Supérieure, Lyon, France

  ⨯
• Fara Raymond Koundouno,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Institut National de Santé Publique, Conakry, Guinea, Laboratoire des Fièvres Hémorragiques en Guinée, Université Gamal Abdel Nasser de Conakry, Conakry, Guinea

  ⨯
• Frédéric Petitjean,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Marie-Claire Lamah,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Sandra Diederich,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Friedrich Loeffler Institute–Federal Research Institute for Animal Health, Greifswald, Germany

  ⨯
• Alexis Tounkara,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Geertrui Poelart,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Emmanuel Berbain,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Jean-Michel Dindart,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Sophie Duraffour,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Rega Institute for Medical Research, Leuven, Belgium

  ⨯
• Annabelle Lefevre,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Tamba Leno,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Olivier Peyrouset,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Léonid Irenge,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Belgian Ministry of Defense, Brussels, Belgium

  ⨯
• N’Famara Bangoura,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Romain Palich,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Julia Hinzmann,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Robert Koch Institute, Berlin, Germany

  ⨯
• Annette Kraus,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Public Health Agency of Sweden, Solna, Sweden

  ⨯
• Thierno Sadou Barry,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Sakoba Berette,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• André Bongono,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Mohamed Seto Camara,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Valérie Chanfreau Munoz,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Lanciné Doumbouya,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Souley Harouna,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Patient Mumbere Kighoma,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Fara Roger Koundouno,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Réné Lolamou,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Cécé Moriba Loua,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Vincent Massala,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Kinda Moumouni,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Célia Provost,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Nenefing Samake,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Conde Sekou,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Abdoulaye Soumah,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Isabelle Arnould,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Michel Saa Komano,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Lina Gustin,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Carlotta Berutto,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Diarra Camara,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Fodé Saydou Camara,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Joliene Colpaert,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Léontine Delamou,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Lena Jansson,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Etienne Kourouma,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Maurice Loua,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Kristian Malme,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Emma Manfrin,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• André Maomou,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Adele Milinouno,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Sien Ombelet,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Aboubacar Youla Sidiboun,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Isabelle Verreckt,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Pauline Yombouno,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Anne Bocquin,

  Affiliation Inserm, Laboratoire P4 Jean Mérieux, Lyon, France

  ⨯
• Caroline Carbonnelle,

  Affiliation Inserm, Laboratoire P4 Jean Mérieux, Lyon, France

  ⨯
• Thierry Carmoi,

  Affiliation Service de Santé des Armées, Paris, France

  ⨯
• Pierre Frange,

  Affiliation Assistance Publique–Hôpitaux de Paris, Hôpital Necker–Enfants Malades, Paris, France

  ⨯
• Stéphane Mely,

  Affiliation Inserm, Laboratoire P4 Jean Mérieux, Lyon, France

  ⨯
• Vinh-Kim Nguyen,

  Affiliation Université de Montréal, Montréal, Canada

  ⨯
• Delphine Pannetier,

  Affiliation Inserm, Laboratoire P4 Jean Mérieux, Lyon, France

  ⨯
• Anne-Marie Taburet,

  Affiliation Assistance Publique–Hôpitaux de Paris, Hôpital Bicêtre, Paris, France

  ⨯
• Jean-Marc Treluyer,

  Affiliation Assistance Publique–Hôpitaux de Paris, Hôpital Necker–Enfants Malades, Paris, France

  ⨯
• Jacques Kolie,

  Affiliation Centre de Recherche en Santé Rurale, Maférinya, Guinea

  ⨯
• Raoul Moh,

  Affiliations Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France, Programme PACCI, Abidjan, Côte d’Ivoire

  ⨯
• Minerva Cervantes Gonzalez,

  Affiliations Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France, Assistance Publique–Hôpitaux de Paris, Hôpital Bichat Claude Bernard, Paris, France

  ⨯
• Eeva Kuisma,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Public Health England, Porton Down, United Kingdom

  ⨯
• Britta Liedigk,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

  ⨯
• Didier Ngabo,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Public Health England, Porton Down, United Kingdom

  ⨯
• Martin Rudolf,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

  ⨯
• Ruth Thom,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Public Health England, Porton Down, United Kingdom

  ⨯
• Romy Kerber,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

  ⨯
• Martin Gabriel,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

  ⨯
• Antonino Di Caro,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, National Institute for Infectious Diseases “L. Spallanzani,” Rome, Italy

  ⨯
• Roman Wölfel,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Bundeswehr Institute of Microbiology, Munich, Germany

  ⨯
• Jamal Badir,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Cliniques Universitaires Saint-Luc, Brussels, Belgium

  ⨯
• Mostafa Bentahir,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Belgian Ministry of Defense, Brussels, Belgium

  ⨯
• Yann Deccache,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Belgian Ministry of Defense, Brussels, Belgium

  ⨯
• Catherine Dumont,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Belgian Ministry of Defense, Brussels, Belgium

  ⨯
• Jean-François Durant,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Université Catholique de Louvain, Louvain-la-Neuve, Belgium

  ⨯
• Karim El Bakkouri,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Université Catholique de Louvain, Louvain-la-Neuve, Belgium

  ⨯
• Marie Gasasira Uwamahoro,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Université Catholique de Louvain, Louvain-la-Neuve, Belgium

  ⨯
• Benjamin Smits,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Université Catholique de Louvain, Louvain-la-Neuve, Belgium

  ⨯
• Nora Toufik,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Cliniques Universitaires Saint-Luc, Brussels, Belgium

  ⨯
• Stéphane Van Cauwenberghe,

  Affiliations Biological Light Fieldable Laboratory for Emergencies (B-LiFE)/Belgian First Aid and Support (B-FAST), Brussels, Belgium, Belgian Ministry of Defense, Brussels, Belgium

  ⨯
• Khaled Ezzedine,

  Affiliation Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France

  ⨯
• Eric Dortenzio,

  Affiliation Solidarité Thérapeutique et Initiatives pour la Santé (Solthis), Paris, France

  ⨯
• Louis Pizarro,

  Affiliation Solidarité Thérapeutique et Initiatives pour la Santé (Solthis), Paris, France

  ⨯
• Aurélie Etienne,

  Affiliations Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France, Assistance Publique–Hôpitaux de Paris, Hôpital Bichat Claude Bernard, Paris, France

  ⨯
• Jérémie Guedj,

  Affiliations Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France, Assistance Publique–Hôpitaux de Paris, Hôpital Bichat Claude Bernard, Paris, France

  ⨯
• Alexandra Fizet,

  Affiliations Institut Pasteur, Centre International de Recherche en Infectiologie, Lyon, France, Inserm, Laboratoire P4 Jean Mérieux, Lyon, France

  ⨯
• Eric Barte de Sainte Fare,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Bernadette Murgue,

  Affiliation Inserm, Paris, France

  ⨯
• Tuan Tran-Minh,

  Affiliation Croix Rouge Française, Paris, France

  ⨯
• Christophe Rapp,

  Affiliation Service de Santé des Armées, Paris, France

  ⨯
• Pascal Piguet,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Marc Poncin,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Bertrand Draguez,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Thierry Allaford Duverger,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Solenne Barbe,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Guillaume Baret,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Isabelle Defourny,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Miles Carroll,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Public Health England, Porton Down, United Kingdom, Southampton General Hospital, University of Southampton, Southampton, United Kingdom

  ⨯
• Hervé Raoul,

  Affiliation Inserm, Laboratoire P4 Jean Mérieux, Lyon, France

  ⨯
• Augustin Augier,

  Affiliation ALIMA, Dakar, Senegal

  ⨯
• Serge P. Eholie,

  Affiliations Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France, Programme PACCI, Abidjan, Côte d’Ivoire, Centre Hospitalier Universitaire de Treichville, Abidjan, Côte d’Ivoire

  ⨯
• Yazdan Yazdanpanah,

  Affiliation Assistance Publique–Hôpitaux de Paris, Hôpital Bichat Claude Bernard, Paris, France

  ⨯
• Claire Levy-Marchal,

  Affiliation Inserm, Paris, France

  ⨯
• Annick Antierrens,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Michel Van Herp,

  Affiliation Médecins Sans Frontières Belgique, Brussels, Belgium

  ⨯
• Stephan Günther,

  Affiliations European Mobile Laboratory Project, Hamburg, Germany, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

  ⨯
• Xavier de Lamballerie,

  Affiliation Université Aix Marseille, Institut de Recherche pour le Développement, École des Hautes Études en Santé Publique, EPV, Marseille, France

  ⨯
• Sakoba Keïta,

  Affiliation Cellule de Coordination Nationale de Lutte contre la Maladie à Virus Ebola, Conakry, Guinea

  ⨯
• France Mentre,

  Affiliations Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France, Assistance Publique–Hôpitaux de Paris, Hôpital Bichat Claude Bernard, Paris, France

  ⨯
• Xavier Anglaret ,

  Contributed equally to this work with: Xavier Anglaret, Denis Malvy

  * E-mail: Xavier.Anglaret@isped.u-bordeaux2.fr (XA); Denis.Malvy@chu-bordeaux.fr (DM)

  Affiliations Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France, Programme PACCI, Abidjan, Côte d’Ivoire

  ⨯
• Denis Malvy ,

  Contributed equally to this work with: Xavier Anglaret, Denis Malvy

  * E-mail: Xavier.Anglaret@isped.u-bordeaux2.fr (XA); Denis.Malvy@chu-bordeaux.fr (DM)

  Affiliations Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France

  ⨯
•  [ ... ],
• JIKI Study Group

  ¶All authors are members of the JIKI Study Group.

  ⨯
• [ view all ]
• [ view less ]