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Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways
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Chen-Yi Tang, Mengrui Wu, Dongfeng Zhao, Diep Edwards, Abigail McVicar, Yuan Luo, Guochun Zhu, Yongjun Wang, Hou-De Zhou, Wei Chen, Yi-Ping Li
Research Article |
published 21 Jan 2021
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1009233
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Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts
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Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori
Research Article |
published 30 Nov 2020
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1009169
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Lack of reproducibility in osteocalcin-deficient mice
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Takeshi Moriishi, Toshihisa Komori
Formal Comment |
published 26 Jun 2020
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008939
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Osteocalcin promotes bone mineralization but is not a hormone
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Stavros C. Manolagas
Perspective |
published 02 Jun 2020
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008714
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Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass
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Takeshi Moriishi, Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano, Tomoka Hasegawa, Toshihiro Miyazaki, Wenguang Liu, Ryo Fukuyama, Yuying Wang, Hisato Komori, Xin Qin, Norio Amizuka, Toshihisa Komori
Research Article |
published 28 May 2020
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008586
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Congenital lipodystrophy induces severe osteosclerosis
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Wei Zou, Nidhi Rohatgi, Jonathan R. Brestoff, Yan Zhang, Erica L. Scheller, Clarissa S. Craft, Michael D. Brodt, Nicole Migotsky, Matthew J. Silva, Charles A. Harris, Steven L. Teitelbaum
Research Article |
published 24 Jun 2019
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008244
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BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development
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Kohei Kitami, Megumi Kitami, Masaru Kaku, Bin Wang, Yoshihiro Komatsu
Research Article |
published 02 May 2018
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1007340
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Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis
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Gretl Hendrickx, Vere M. Borra, Ellen Steenackers, Timur A. Yorgan, Christophe Hermans, Eveline Boudin, Jérôme J. Waterval, Ineke D. C. Jansen, Tolunay Beker Aydemir, Niels Kamerling, Geert J. Behets, Christine Plumeyer, Patrick C. D’Haese, Björn Busse, Vincent Everts, Martin Lammens, Geert Mortier, Robert J. Cousins, Thorsten Schinke, Robert J. Stokroos, Johannes J. Manni, Wim Van Hul
Research Article |
published 05 Apr 2018
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1007321
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mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway
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Bin Huang, Yongkui Wang, Wenhao Wang, Juan Chen, Pinglin Lai, Zhongyu Liu, Bo Yan, Song Xu, Zhongmin Zhang, Chun Zeng, Limin Rong, Bin Liu, Daozhang Cai, Dadi Jin, Xiaochun Bai
Research Article |
published 04 Aug 2015
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1005426
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The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation
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Alvin J. M. Ng, Mannu K. Walia, Monique F. Smeets, Anthony J. Mutsaers, Natalie A. Sims, Louise E. Purton, Nicole C. Walsh, T. John Martin, Carl R. Walkley
Research Article |
published 10 Apr 2015
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1005160
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A Gain-of-Function Mutation in Tnni2 Impeded Bone Development through Increasing Hif3a Expression in DA2B Mice
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Xiaoquan Zhu, Fengchao Wang, Yanyang Zhao, Peng Yang, Jun Chen, Hanzi Sun, Lei Liu, Wenjun Li, Lin Pan, Yanru Guo, Zhaohui Kou, Yu Zhang, Cheng Zhou, Jiang He, Xue Zhang, Jianxin Li, Weitian Han, Jian Li, Guanghui Liu, Shaorong Gao, Ze Yang
Research Article |
published 23 Oct 2014
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1004589
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WNT7B Promotes Bone Formation in part through mTORC1
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Jianquan Chen, Xiaolin Tu, Emel Esen, Kyu Sang Joeng, Congxin Lin, Jeffrey M. Arbeit, Markus A. Rüegg, Michael N. Hall, Liang Ma, Fanxin Long
Research Article |
published 30 Jan 2014
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1004145
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MAML1 Enhances the Transcriptional Activity of Runx2 and Plays a Role in Bone Development
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Takashi Watanabe, Toshinao Oyama, Maki Asada, Daisuke Harada, Yoshiaki Ito, Masayo Inagawa, Yutaka Suzuki, Sumio Sugano, Ken-ichi Katsube, Gerard Karsenty, Toshihisa Komori, Motoo Kitagawa, Hiroshi Asahara
Research Article |
published 10 Jan 2013
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1003132
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Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone
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Giorgio Giacomo Galli, Kristian Honnens de Lichtenberg, Matteo Carrara, Wolfgang Hans, Manuela Wuelling, Bettina Mentz, Hinke Arnolda Multhaupt, Cathrine Kolster Fog, Klaus Thorleif Jensen, Juri Rappsilber, Andrea Vortkamp, Les Coulton, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Raffaele Adolfo Calogero, John Robert Couchman, Anders Henrik Lund
Research Article |
published 10 May 2012
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1002711
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Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1
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Xiaolin Tu, Jianquan Chen, Joohyun Lim, Courtney M. Karner, Seung-Yon Lee, Julia Heisig, Cornelia Wiese, Kameswaran Surendran, Raphael Kopan, Manfred Gessler, Fanxin Long
Research Article |
published 22 Mar 2012
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1002577
