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Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus
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Yvet Opmeer, Frank G. van Steenbeek, Claudia Rozendom, Hille Fieten, Montse M. Diaz Espineira, Qurine E. M. Stassen, Peter J. van Kooten, Victor P. M. G. Rutten, Marjo K. Hytönen, Hannes Lohi, Paul J. J. Mandigers, Peter A. Leegwater
Research Article |
published 02 Jan 2025
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1011538
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COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection
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Yuxuan Wang, Suri Guga, Kejia Wu, Zoe Khaw, Konstantinos Tzoumkas, Phil Tombleson, Mary E. Comeau, Carl D. Langefeld, Deborah S. Cunninghame Graham, David L. Morris, Timothy J. Vyse
Research Article |
published 03 Nov 2022
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1010253
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A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
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Anurag Verma, Noah L. Tsao, Lauren O. Thomann, Yuk-Lam Ho, Sudha K. Iyengar, Shiuh-Wen Luoh, Rotonya Carr, Dana C. Crawford, Jimmy T. Efird, Jennifer E. Huffman, Adriana Hung, Kerry L. Ivey, Michael G. Levin, Julie Lynch, Pradeep Natarajan, Saiju Pyarajan, Alexander G. Bick, Lauren Costa, Giulio Genovese, Richard Hauger, Ravi Madduri, Gita A. Pathak, Renato Polimanti, Benjamin Voight, Marijana Vujkovic, Seyedeh Maryam Zekavat, Hongyu Zhao, Marylyn D. Ritchie, VA Million Veteran Program COVID-19 Science Initiative , Kyong-Mi Chang, Kelly Cho, Juan P. Casas, Philip S. Tsao, J. Michael Gaziano, Christopher O’Donnell, Scott M. Damrauer, Katherine P. Liao
Research Article |
published 28 Apr 2022
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1010113
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Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis
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Aimee L. Hanson, International Genetics of Ankylosing Spondylitis Consortium , Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Lê Cao, Tony J. Kenna, Matthew A. Brown
Research Article |
published 17 Aug 2020
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008906
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Leveraging gene co-expression patterns to infer trait-relevant tissues in genome-wide association studies
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Lulu Shang, Jennifer A. Smith, Xiang Zhou
Research Article |
published 20 Apr 2020
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008734
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Evaluating the strength of genetic results: Risks and responsibilities
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Gregory S. Barsh, Gregory M. Cooper, Gregory P. Copenhaver, Giorgio Sirugo, Hua Tang, Scott M. Williams
Editorial |
published 11 Oct 2019
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008437
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Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease
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Carles Vilariño-Güell, Alexander Zimprich, Filippo Martinelli-Boneschi, Bruno Herculano, Zhe Wang, Fuencisla Matesanz, Elena Urcelay, Koen Vandenbroeck, Laura Leyva, Denis Gris, Charbel Massaad, Jacqueline A. Quandt, Anthony L. Traboulsee, Mary Encarnacion, Cecily Q. Bernales, Jordan Follett, Irene M. Yee, Maria G. Criscuoli, Angela Deutschländer, Eva M. Reinthaler, Tobias Zrzavy, Elisabetta Mascia, Andrea Zauli, Federica Esposito, Antonio Alcina, Guillermo Izquierdo, Laura Espino-Paisán, Jorge Mena, Alfredo Antigüedad, Patricia Urbaneja-Romero, Jesús Ortega-Pinazo, Weihong Song, A. Dessa Sadovnick
Research Article |
published 06 Jun 2019
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008180
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Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians
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Julio E. Molineros, Loren L. Looger, Kwangwoo Kim, Yukinori Okada, Chikashi Terao, Celi Sun, Xu-jie Zhou, Prithvi Raj, Yuta Kochi, Akari Suzuki, Shuji Akizuki, Shuichiro Nakabo, So-Young Bang, Hye-Soon Lee, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Yong-Beom Park, Jung-Yoon Choe, Seung-Cheol Shim, Shin-Seok Lee, Xiaoxia Zuo, Kazuhiko Yamamoto, Quan-Zhen Li, Nan Shen, Lauren L. Porter, John B. Harley, Kek Heng Chua, Hong Zhang, Edward K. Wakeland, Betty P. Tsao, Sang-Cheol Bae, Swapan K. Nath
Research Article |
published 25 Apr 2019
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008092
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Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis
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Zhixiu Li, Servet Akar, Handan Yarkan, Sau Kuen Lee, Pınar Çetin, Gerçek Can, Gökce Kenar, Fernur Çapa, Omer Nuri Pamuk, Yavuz Pehlivan, Katie Cremin, Erika De Guzman, Jessica Harris, Lawrie Wheeler, Ahmadreza Jamshidi, Mahdi Vojdanian, Elham Farhadi, Nooshin Ahmadzadeh, Zeynep Yüce, Ediz Dalkılıç, Dilek Solmaz, Berrin Akın, Salim Dönmez, İsmail Sarı, Paul J. Leo, Tony J. Kenna, Fatos Önen, Mahdi Mahmoudi, Matthew A. Brown, Nurullah Akkoc
Research Article |
published 04 Apr 2019
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1008038
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A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene
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Michael Hecker, Nina Boxberger, Nicole Illner, Brit Fitzner, Ina Schröder, Alexander Winkelmann, Ales Dudesek, Stefanie Meister, Dirk Koczan, Peter Lorenz, Hans-Jürgen Thiesen, Uwe Klaus Zettl
Research Article |
published 07 Feb 2019
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1007961
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Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry
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Calvin Chi, Xiaorong Shao, Brooke Rhead, Edlin Gonzales, Jessica B. Smith, Anny H. Xiang, Jennifer Graves, Amy Waldman, Timothy Lotze, Teri Schreiner, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jayne Ness, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Tanuja Chitnis, Soe Mar, Anita Belman, Theron Charles Casper, John Rose, Manikum Moodley, Mary Rensel, Moses Rodriguez, Benjamin Greenberg, Llana Kahn, Jennifer Rubin, Catherine Schaefer, Emmanuelle Waubant, Annette Langer-Gould, Lisa F. Barcellos
Research Article |
published 17 Jan 2019
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1007808
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Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis
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Rebecca Darlay, Kristin L. Ayers, George F. Mells, Lynsey S. Hall, Jimmy Z. Liu, Mohamed A. Almarri, Graeme J. Alexander, David E. Jones, Richard N. Sandford, Carl A. Anderson, Heather J. Cordell
Research Article |
published 03 Dec 2018
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1007833
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Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
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Manuel A. Rivas, Brandon E. Avila, Jukka Koskela, Hailiang Huang, Christine Stevens, Matti Pirinen, Talin Haritunians, Benjamin M. Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P. Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Monkol Lek, Konrad J. Karczewski, Jonathan Bloom, Eric V. Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, International IBD Genetics Consortium , NIDDK IBD Genetics Consortium , T2D-GENES Consortium , Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W. Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Aarno Palotie, Steven R. Brant, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Rinse K. Weersma, Andre Franke, Luke Jostins, Carl A. Anderson, Jeffrey C. Barrett, Daniel G. MacArthur, Chaim Jalas, Harry Sokol, Ramnik J. Xavier, Ann Pulver, Judy H. Cho, Dermot P. B. McGovern, Mark J. Daly
Research Article |
published 24 May 2018
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1007329
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Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease
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Christopher A. Odhams, Deborah S. Cunninghame Graham, Timothy J. Vyse
Research Article |
published 23 Oct 2017
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1007071
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Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status
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Michele D. Binder, Andrew D. Fox, Daniel Merlo, Laura J. Johnson, Lauren Giuffrida, Sarah E. Calvert, Rainer Akkermann, Gerry Z. M. Ma, ANZgene , Ashwyn A. Perera, Melissa M. Gresle, Louise Laverick, Grace Foo, Marzena J. Fabis-Pedrini, Timothy Spelman, Margaret A. Jordan, Alan G. Baxter, Simon Foote, Helmut Butzkueven, Trevor J. Kilpatrick, Judith Field
Research Article |
published 18 Mar 2016
PLOS Genetics
https://doi.org/10.1371/journal.pgen.1005853
