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PLOS Computational Biology  
A mechanistic modeling framework reveals the key principles underlying tumor metabolism

Shubham Tripathi, Jun Hyoung Park, Shivanand Pudakalakatti, Pratip K. Bhattacharya, Benny Abraham Kaipparettu, Herbert Levine

Research Article | published 11 Feb 2022 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1009841

Views: 3381Citations: 8Saves: 25 • Shares: 8

Inclusion of maintenance energy improves the intracellular flux predictions of CHO

Diana Széliová, Jerneja Štor, Isabella Thiel, Marcus Weinguny, Michael Hanscho, Gabriele Lhota, Nicole Borth, Jürgen Zanghellini, David E. Ruckerbauer, Isabel Rocha

Research Article | published 11 Jun 2021 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1009022

Views: 3111Citations: 9Saves: 43 • Shares: 3

Unveiling dynamic metabolic signatures in human induced pluripotent and neural stem cells

João Vasconcelos e Sá, Daniel Simão, Ana P. Terrasso, Marta M. Silva, Catarina Brito, Inês A. Isidro, Paula M. Alves, Manuel J. T. Carrondo

Research Article | published 16 Apr 2020 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1007780

Views: 3220Citations: 6Saves: 20 • Shares: 4

Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model

Mahua Roy, Stacey D. Finley

Research Article | published 11 Jun 2019 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1007053

Views: 4596Citations: 30Saves: 72 • Shares: 30

Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors

Mengrou Shan, David Dai, Arunodai Vudem, Jeffrey D. Varner, Abraham D. Stroock

Research Article | published 07 Dec 2018 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1006584

Views: 6597Citations: 37Saves: 90 • Shares: 7

A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

Chiara Damiani, Riccardo Colombo, Daniela Gaglio, Fabrizia Mastroianni, Dario Pescini, Hans Victor Westerhoff, Giancarlo Mauri, Marco Vanoni, Lilia Alberghina

Research Article | published 28 Sep 2017 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1005758

Views: 8587Citations: 81Saves: 97 • Shares: 12

Elucidation of Genetic Interactions in the Yeast GATA-Factor Network Using Bayesian Model Selection

Andreas Milias-Argeitis, Ana Paula Oliveira, Luca Gerosa, Laura Falter, Uwe Sauer, John Lygeros

Research Article | published 11 Mar 2016 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1004784

Views: 3883Citations: 8Saves: 54 • Shares: 6

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies

Benedikt Frieg, Boris Görg, Nadine Homeyer, Verena Keitel, Dieter Häussinger, Holger Gohlke

Research Article | published 02 Feb 2016 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1004693

Views: 5103Citations: 33Saves: 56 • Shares: 5

A Systematic Framework for Molecular Dynamics Simulations of Protein Post-Translational Modifications

Drazen Petrov, Christian Margreitter, Melanie Grandits, Chris Oostenbrink, Bojan Zagrovic

Research Article | published 18 Jul 2013 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1003154

Views: 11334Citations: 101Saves: 158 • Shares: 3

Are Long-Range Structural Correlations Behind the Aggregration Phenomena of Polyglutamine Diseases?

Mahmoud Moradi, Volodymyr Babin, Christopher Roland, Celeste Sagui

Research Article | published 26 Apr 2012 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1002501

Views: 4249Citations: 19Saves: 0 • Shares: 0

Genome-Scale Metabolic Modeling Elucidates the Role of Proliferative Adaptation in Causing the Warburg Effect

Tomer Shlomi, Tomer Benyamini, Eyal Gottlieb, Roded Sharan, Eytan Ruppin

Research Article | published 10 Mar 2011 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1002018

Views: 17062Citations: 219Saves: 416 • Shares: 0

Achieving Optimal Growth through Product Feedback Inhibition in Metabolism

Sidhartha Goyal, Jie Yuan, Thomas Chen, Joshua D. Rabinowitz, Ned S. Wingreen

Research Article | published 03 Jun 2010 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1000802

Views: 8726Citations: 44Saves: 150 • Shares: 0

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences

Vinal V. Lakhani, Feng Ding, Nikolay V. Dokholyan

Research Article | published 29 Apr 2010 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1000772

Views: 6985Citations: 89Saves: 104 • Shares: 0

Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases

Sagar D Khare, Feng Ding, Kenneth N Gwanmesia, Nikolay V Dokholyan

Research Article | published 26 Aug 2005 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.0010030

Views: 12572Citations: 92Saves: 91 • Shares: 0

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