Search Results | PLOS Biology

The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity

Liam C. Hunt, Michelle Curley, Kudzai Nyamkondiwa, Anna Stephan, Jianqin Jiao, Kanisha Kavdia, Vishwajeeth R. Pagala, Junmin Peng, Fabio Demontis

Research Article | published 29 Jan 2025 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002998

Views: 1103 • Citations: 1 • Saves: 0 • Shares: 2

Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice

Kenji Uno, Takuya Uchino, Takashi Suzuki, Yohei Sayama, Naoki Edo, Kiyoko Uno-Eder, Koji Morita, Toshio Ishikawa, Miho Koizumi, Hiroaki Honda, Hideki Katagiri, Kazuhisa Tsukamoto

Research Article | published 24 Jan 2025 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002955

Views: 1044 • Citations: 0 • Saves: 0 • Shares: 10

Baf155 regulates skeletal muscle metabolism via HIF-1a signaling

Jong-Seol Kang, Dongha Kim, Joonwoo Rhee, Ji-Yun Seo, Inkuk Park, Ji-Hoon Kim, Daewon Lee, WonUk Lee, Ye Lynne Kim, Kyusang Yoo, Sunghwan Bae, Jongkyeong Chung, Rho Hyun Seong, Young-Yun Kong

Research Article | published 21 Jul 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002192

Views: 2730 • Citations: 6 • Saves: 15 • Shares: 7

Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β

Xiao Chen Shi, Bo Xia, Jian Feng Zhang, Rui Xin Zhang, Dan Yang Zhang, Huan Liu, Bao Cai Xie, Yong Liang Wang, Jiang Wei Wu

Research Article | published 27 Apr 2022 PLOS Biology

https://doi.org/10.1371/journal.pbio.3001619

Views: 4589 • Citations: 9 • Saves: 13 • Shares: 5

Camptothecin effectively treats obesity in mice through GDF15 induction

Jun Feng Lu, Meng Qing Zhu, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Rui Xin Zhang, Bo Xia, Jiang Wei Wu

Research Article | published 24 Feb 2022 PLOS Biology

https://doi.org/10.1371/journal.pbio.3001517

Views: 8309 • Citations: 27 • Saves: 48 • Shares: 21

Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency

Lei Xiong, Kai Zhao, Yu Cao, Hao-Han Guo, Jin-Xiu Pan, Xiao Yang, Xiao Ren, Lin Mei, Wen-Cheng Xiong

Research Article | published 01 Jun 2020 PLOS Biology

https://doi.org/10.1371/journal.pbio.3000731

Views: 6394 • Citations: 20 • Saves: 27 • Shares: 17

Dynamic enhancers control skeletal muscle identity and reprogramming

Krithika Ramachandran, Madhavi D. Senagolage, Meredith A. Sommars, Christopher R. Futtner, Yasuhiro Omura, Amanda L. Allred, Grant D. Barish

Methods and Resources | published 07 Oct 2019 PLOS Biology

https://doi.org/10.1371/journal.pbio.3000467

Views: 11210 • Citations: 42 • Saves: 82 • Shares: 29

Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock

Kenneth Allen Dyar, Michaël Jean Hubert, Ashfaq Ali Mir, Stefano Ciciliot, Dominik Lutter, Franziska Greulich, Fabiana Quagliarini, Maximilian Kleinert, Katrin Fischer, Thomas Oliver Eichmann, Lauren Emily Wright, Marcia Ivonne Peña Paz, Alberto Casarin, Vanessa Pertegato, Vanina Romanello, Mattia Albiero, Sara Mazzucco, Rosario Rizzuto, Leonardo Salviati, Gianni Biolo, Bert Blaauw, Stefano Schiaffino, N. Henriette Uhlenhaut

Methods and Resources | published 10 Aug 2018 PLOS Biology

https://doi.org/10.1371/journal.pbio.2005886

Views: 19062 • Citations: 129 • Saves: 164 • Shares: 138

Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle

Sofi G. Julien, Sun-Yee Kim, Reinhard Brunmeir, Joanna R. Sinnakannu, Xiaojia Ge, Hongyu Li, Wei Ma, Jadegoud Yaligar, Bhanu Prakash KN, Sendhil S. Velan, Pia V. Röder, Qiongyi Zhang, Choon Kiat Sim, Jingyi Wu, Marta Garcia-Miralles, Mahmoud A. Pouladi, Wei Xie, Craig McFarlane, Weiping Han, Feng Xu

Research Article | published 16 Feb 2017 PLOS Biology

https://doi.org/10.1371/journal.pbio.1002597

Views: 12915 • Citations: 40 • Saves: 49 • Shares: 17

Where Have All the Giants Gone? How Animals Deal with the Problem of Size

Taylor J. M. Dick, Christofer J. Clemente

Unsolved Mystery | published 11 Jan 2017 PLOS Biology

https://doi.org/10.1371/journal.pbio.2000473

Views: 22706 • Citations: 57 • Saves: 159 • Shares: 159

Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical Uniqueness

Katarzyna Bozek, Yuning Wei, Zheng Yan, Xiling Liu, Jieyi Xiong, Masahiro Sugimoto, Masaru Tomita, Svante Pääbo, Raik Pieszek, Chet C. Sherwood, Patrick R. Hof, John J. Ely, Dirk Steinhauser, Lothar Willmitzer, Jens Bangsbo, Ola Hansson, Josep Call, Patrick Giavalisco, Philipp Khaitovich

Research Article | published 27 May 2014 PLOS Biology

https://doi.org/10.1371/journal.pbio.1001871

Views: 55062 • Citations: 86 • Saves: 245 • Shares: 100

The Fly Muscles in on Glycogen Autophagy