Search Results | PLOS Biology

Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion

Harriet V. Mears, George R. Young, Theo Sanderson, Ruth Harvey, Jamie Barrett-Rodger, Rebecca Penn, Vanessa Cowton, Wilhelm Furnon, Giuditta De Lorenzo, Margaret Crawford, Daniel M. Snell, Ashley S. Fowler, Anob M. Chakrabarti, Saira Hussain, Ciarán Gilbride, Edward Emmott, Katja Finsterbusch, Jakub Luptak, Thomas P. Peacock, Jérôme Nicod, Arvind H. Patel, Massimo Palmarini, Emma Wall, Bryan Williams, Sonia Gandhi, Charles Swanton, David L. V. Bauer

Research Article | published 21 Jan 2025 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002982

Views: 1921 • Citations: 2 • Saves: 13 • Shares: 0

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

Jérémie Le Pen, Gabrielle Paniccia, Volker Kinast, Marcela Moncada-Velez, Alison W. Ashbrook, Michael Bauer, H.-Heinrich Hoffmann, Ana Pinharanda, Inna Ricardo-Lax, Ansgar F. Stenzel, Edwin A. Rosado-Olivieri, Kenneth H. Dinnon III, William C. Doyle, Catherine A. Freije, Seon-Hui Hong, Danyel Lee, Tyler Lewy, Joseph M. Luna, Avery Peace, Carltin Schmidt, William M. Schneider, Roni Winkler, Elaine Z. Yip, Chloe Larson, Timothy McGinn, Miriam-Rose Menezes, Lavoisier Ramos-Espiritu, Priyam Banerjee, John T. Poirier, Francisco J. Sànchez-Rivera, Aurélie Cobat, Qian Zhang, Jean-Laurent Casanova, Thomas S. Carroll, J. Fraser Glickman, Eleftherios Michailidis, Brandon Razooky, Margaret R. MacDonald, Charles M. Rice

Research Article | published 24 Sep 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002767

Views: 3675 • Citations: 3 • Saves: 18 • Shares: 17

The evolutionary safety of mutagenic drugs should be assessed before drug approval

Gabriela Lobinska, Vyacheslav Tretyachenko, Orna Dahan, Martin A. Nowak, Yitzhak Pilpel

Perspective | published 15 Mar 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002570

Views: 1894 • Citations: 0 • Saves: 6 • Shares: 17

Developing inhibitory peptides against SARS-CoV-2 envelope protein

Ramsey Bekdash, Kazushige Yoshida, Manoj S. Nair, Lauren Qiu, Johnathan Ahdout, Hsiang-Yi Tsai, Kunihiro Uryu, Rajesh K. Soni, Yaoxing Huang, David D. Ho, Masayuki Yazawa

Research Article | published 14 Mar 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002522

Views: 2671 • Citations: 1 • Saves: 9 • Shares: 121

Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants

Timothy W. Russell, Hermaleigh Townsley, Sam Abbott, Joel Hellewell, Edward J. Carr, Lloyd A. C. Chapman, Rachael Pung, Billy J. Quilty, David Hodgson, Ashley S. Fowler, Lorin Adams, Chris Bailey, Harriet V. Mears, Ruth Harvey, Bobbi Clayton, Nicola O’Reilly, Yenting Ngai, Jerome Nicod, Steve Gamblin, Bryan Williams, Sonia Gandhi, Charles Swanton, Rupert Beale, David L. V. Bauer, Emma C. Wall, Adam J. Kucharski

Research Article | published 30 Jan 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002463

Views: 3478 • Citations: 8 • Saves: 25 • Shares: 33

Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication

Spyros Lytras, Arthur Wickenhagen, Elena Sugrue, Douglas G. Stewart, Simon Swingler, Anna Sims, Hollie Jackson Ireland, Emma L. Davies, Eliza M. Ludlam, Zhuonan Li, Joseph Hughes, Sam J. Wilson

Short Reports | published 28 Nov 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002398

Views: 3828 • Citations: 5 • Saves: 7 • Shares: 166

Minding the “T”s beyond the “B”s: Shaping vaccines for future pandemics

Shirin Kalimuddin, Eng Eong Ooi

Perspective | published 07 Nov 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002351