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The end of the genetic paradigm of cancer

Sui Huang, Ana M. Soto, Carlos Sonnenschein

Essay | published 18 Mar 2025 PLOS Biology

https://doi.org/10.1371/journal.pbio.3003052

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A high-resolution two-step evolution experiment in yeast reveals a shift from pleiotropic to modular adaptation

Grant Kinsler, Yuping Li, Gavin Sherlock, Dmitri A. Petrov

Research Article | published 05 Dec 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002848

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Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits

Jessica E. Buddle, Lucy M. Thompson, Anne S. Williams, Rosanna C. T. Wright, William M. Durham, Claire E. Turner, Roy R. Chaudhuri, Michael A. Brockhurst, Robert P. Fagan

Research Article | published 15 Aug 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002741

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Robust genetic codes enhance protein evolvability

Hana Rozhoňová, Carlos Martí-Gómez, David M. McCandlish, Joshua L. Payne

Research Article | published 16 May 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002594

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Promoter recruitment drives the emergence of proto-genes in a long-term evolution experiment with Escherichia coli

Md. Hassan uz-Zaman, Simon D’Alton, Jeffrey E. Barrick, Howard Ochman

Research Article | published 07 May 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002418

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The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscission

Inbar Dvilansky, Yarin Altaras, Nikita Kamenetsky, Dikla Nachmias, Natalie Elia

Research Article | published 30 Apr 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002327

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Bridging integrator 1 fragment accelerates tau aggregation and propagation by enhancing clathrin-mediated endocytosis in mice

Xingyu Zhang, Li Zou, Li Tang, Min Xiong, Xiao-Xin Yan, Lanxia Meng, Guiqin Chen, Jing Xiong, Shuke Nie, Zhaohui Zhang, Qiang Chen, Zhentao Zhang

Research Article | published 11 Jan 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002470

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High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes

Sheida Heidarian, Andrei Guliaev, Hervé Nicoloff, Karin Hjort, Dan I. Andersson

Short Reports | published 04 Jan 2024 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002457

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A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide

Lujie Liang, Lan-Lan Zhong, Lin Wang, Dianrong Zhou, Yaxin Li, Jiachen Li, Yong Chen, Wanfei Liang, Wenjing Wei, Chenchen Zhang, Hui Zhao, Lingxuan Lyu, Nicole Stoesser, Yohei Doi, Fang Bai, Siyuan Feng, Guo-Bao Tian

Research Article | published 13 Dec 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002433

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Distribution and molecular evolution of the anti-CRISPR family AcrIF7

Wendy Figueroa, Adrian Cazares, Daniel Cazares, Yi Wu, Ana de la Cruz, Martin Welch, Luis Kameyama, Franklin L. Nobrega, Gabriel Guarneros

Research Article | published 21 Apr 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002072

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CRISPR-Cas effector specificity and cleavage site determine phage escape outcomes

Michael A. Schelling, Giang T. Nguyen, Dipali G. Sashital

Research Article | published 14 Apr 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002065

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In the business of base editors: Evolution from bench to bedside

Elizabeth M. Porto, Alexis C. Komor

Essay | published 12 Apr 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3002071

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Gain-of-function mutations in Trim71 linked to congenital hydrocephalus

Yingying Chen, Xianfa Yang, Naihe Jing

Primer | published 09 Feb 2023 PLOS Biology

https://doi.org/10.1371/journal.pbio.3001993

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Hypermutator strains of Pseudomonas aeruginosa reveal novel pathways of resistance to combinations of cephalosporin antibiotics and beta-lactamase inhibitors

Augusto Dulanto Chiang, Prashant P. Patil, Lidia Beka, Jung-Ho Youn, Adrien Launay, Robert A. Bonomo, Pavel P. Khil, John P. Dekker

Research Article | published 18 Nov 2022 PLOS Biology

https://doi.org/10.1371/journal.pbio.3001878

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DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes

Akihiro Kuno, Yoshihisa Ikeda, Shinya Ayabe, Kanako Kato, Kotaro Sakamoto, Sayaka R. Suzuki, Kento Morimoto, Arata Wakimoto, Natsuki Mikami, Miyuki Ishida, Natsumi Iki, Yuko Hamada, Megumi Takemura, Yoko Daitoku, Yoko Tanimoto, Tra Thi Huong Dinh, Kazuya Murata, Michito Hamada, Masafumi Muratani, Atsushi Yoshiki, Fumihiro Sugiyama, Satoru Takahashi, Seiya Mizuno

Methods and Resources | published 18 Jan 2022 PLOS Biology

https://doi.org/10.1371/journal.pbio.3001507

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