Challenges in detecting and predicting adverse drug events via distributed analysis of electronic health record data from German university hospitals

• Anna Maria Wermund,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, Bonn, Germany

  https://orcid.org/0000-0002-5735-0197

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• Torsten Thalheim,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliations Interdisciplinary Centre for Bioinformatics, Leipzig University, Leipzig, Germany, Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, Leipzig, Germany, Deutsches Biomasseforschungszentrum gGmbH, Leipzig, Germany

  https://orcid.org/0000-0001-5489-7405

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• André Medek,

  Roles Data curation, Software, Validation, Writing – review & editing

  Affiliation Medical & Scientific Technology Development & Coordination (MWTek), University Hospital Bonn, Bonn, Germany

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• Florian Schmidt,

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliation Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, Leipzig, Germany

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• Thomas Peschel,

  Roles Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, Leipzig, Germany

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• Alexander Strübing,

  Roles Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, Leipzig, Germany

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• Daniel Neumann,

  Roles Project administration, Validation, Writing – review & editing

  Affiliation Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, Leipzig, Germany

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• André Scherag,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Institute of Medical Statistics, Computer and Data Sciences (IMSID), Jena University Hospital – Friedrich Schiller University Jena, Jena, Germany

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• Markus Loeffler,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, Leipzig, Germany

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• Miriam Kesselmeier ,

  Contributed equally to this work with: Miriam Kesselmeier, Ulrich Jaehde

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft

  Affiliation Institute of Medical Statistics, Computer and Data Sciences (IMSID), Jena University Hospital – Friedrich Schiller University Jena, Jena, Germany

  https://orcid.org/0000-0001-6462-2579

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• Ulrich Jaehde ,

  Contributed equally to this work with: Miriam Kesselmeier, Ulrich Jaehde

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: u.jaehde@uni-bonn.de

  Affiliation Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, Bonn, Germany

  https://orcid.org/0000-0002-2493-7370

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• for the POLAR_MI Consortium

  ¶Membership of the POLAR_MI Consortium is provided in the S1 File.

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