Deep learning to predict rapid progression of Alzheimer’s disease from pooled clinical trials: A retrospective study

• Xiaotian Ma ,

  Contributed equally to this work with: Xiaotian Ma, Madison Shyer

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Health Data Science and Artificial Intelligence, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  https://orcid.org/0009-0005-9462-2170

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• Madison Shyer ,

  Contributed equally to this work with: Xiaotian Ma, Madison Shyer

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  https://orcid.org/0000-0002-8166-1868

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• Kristofer Harris,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  https://orcid.org/0000-0003-1250-6650

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• Dulin Wang,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Health Data Science and Artificial Intelligence, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Yu-Chun Hsu,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Health Data Science and Artificial Intelligence, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Christine Farrell,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Nathan Goodwin,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Sahar Anjum,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Avram S. Bukhbinder,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Division of Pediatric Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Sarah Dean,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Tanveer Khan,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• David Hunter,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Paul E. Schulz,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Xiaoqian Jiang,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Department of Health Data Science and Artificial Intelligence, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Yejin Kim

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  * E-mail: Yejin.Kim@uth.tmc.edu

  Affiliation Department of Health Data Science and Artificial Intelligence, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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