About the Authors

Valentin Liévin

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations DTU Compute, Technical University of Denmark, Lyngby, Denmark, FindZebra, Denmark

Jonas Meinertz Hansen

Roles Data curation, Investigation, Methodology, Resources, Software, Writing – review & editing

Affiliation FindZebra, Denmark

Allan Lund

Roles Validation, Writing – review & editing

Affiliation Centre Inherited Metabolic Diseases, Department of Clinical Genetics and Paediatrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen Ø, Denmark

Deborah Elstein

Roles Validation, Writing – review & editing

Affiliation Independent consultant; Jerusalem, Israel

Mads Emil Matthiesen

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliation FindZebra, Denmark

Kaisa Elomaa

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Takeda Oy, Helsinki, Finland

Kaja Zarakowska

Roles Project administration, Supervision, Writing – review & editing

Current address: UCB Farchim SA, Bulle, Switzerland

Affiliation Takeda Pharmaceuticals International AG, Zürich, Switzerland

Iris Himmelhan

Roles Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

Affiliation Takeda Pharmaceuticals International AG, Zürich, Switzerland

Jaco Botha

Roles Data curation, Formal analysis, Methodology, Resources, Writing – review & editing

Affiliation Takeda Pharmaceuticals International AG, Zürich, Switzerland

Hanne Borgeskov

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of Clinical Pharmacology, Aalborg University Hospital, Aalborg, Denmark

Ole Winther

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

ole.winther@bio.ku.dk

Affiliations DTU Compute, Technical University of Denmark, Lyngby, Denmark, FindZebra, Denmark, Department of Biology, University of Copenhagen, Copenhagen N, Denmark, Genomic Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen Ø, Denmark

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: KE, IH and JB are employed by Takeda and hold Takeda stocks/stock options. HB is a former employee in Takeda Pharma A/S, Denmark, holding a current position at Department of Clinical Pharmacology, Aalborg University Hospital in Denmark. KZ was employed by Takeda at the time of the study and holds Takeda stocks/stock options. OW, MM, VL and JH are employed by FindZebra, which received funding from Takeda for conducting the study. AL received reimbursement from FindZebra for clinical expertise in this study. AL reports also personal consultancy fees and travel grants from Takeda during the study, as well as grant support paid to his institution. DE received consultancy fees from Takeda for clinical expertise in this study.