About the Authors

Kei Watase

Affiliations 21st Century COE program on Brain Integration and Its Disorders, Tokyo Medical and Dental University, Tokyo, Japan , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America , Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America

Jennifer R Gatchel

Affiliation Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America

Yaling Sun

Affiliation Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America

Effat Emamian

Affiliation Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America

Richard Atkinson

Affiliation Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America

Ronald Richman

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America , Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America

Hidehiro Mizusawa

Affiliation 21st Century COE program on Brain Integration and Its Disorders, Tokyo Medical and Dental University, Tokyo, Japan

Harry T Orr

Affiliation Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America

Chad Shaw

Affiliation Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America

Huda Y Zoghbi

To whom correspondence should be addressed. E-mail: hzoghbi@bcm.tmc.edu

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America , Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America , Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America , Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KW and HYZ designed the study. KW, JRG, RA, RR, HM, and CS analyzed the data. KW, JRG, HM, HTO, and HYZ contributed to writing the paper. KW collected data and performed experiments for the study. JRG collected, analyzed, and interpreted data. YS performed immunofluorescence staining, Northern analyses, and mouse breeding and feeding with treated chow. EE and HTO provided some foundation for the current study with initial studies on another animal model using lithium. RA designed the method and collected and analyzed the image data used in preparation of portions of Figure 3. HM contributed to the above activities directly or through discussions with KW. CS participated in statistical analyses.