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Table of Contents: October 2017

Ronald Ma and Barry Popkin discuss a worsening epidemic of childhood and young-onset diabetes, exploring the intergenerational risk factors that must be addressed. Interventions targeting maternal diabetes, gestational diabetes and maternal obesity may not be enough, according to emerging research showing that in utero and early-life nutrition, for example, can be associated with increased risk in offspring of diabetes, obesity and younger-age onset. In this month's Editorial, the authors highlight interventions at different stages of the reproductive cycle and life course that aim to break intergenerational cycles of transmission.

Image Credit: Dani Lurie, Flickr

Editorials

Intergenerational diabetes and obesity—A cycle to break?

Ronald C. W. Ma, Barry M. Popkin

Firearm-Related Injury and Death: A U.S. Health Care Crisis in Need of Health Care Professionals

Darren B. Taichman, Howard Bauchner, Jeffrey M. Drazen, Christine Laine, Larry Peiperl

Essay

When cost-effective interventions are unaffordable: Integrating cost-effectiveness and budget impact in priority setting for global health programs

Alyssa Bilinski, Peter Neumann, Joshua Cohen, Teja Thorat, Katherine McDaniel, Joshua A. Salomon

Policy Forum

Regional initiatives for malaria elimination: Building and maintaining partnerships

Andrew A. Lover, Kelly E. Harvard, Alistair E. Lindawson, Cara Smith Gueye, Rima Shretta, Roly Gosling, Richard Feachem

Research Articles

Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study

Tara Gomes, David N. Juurlink, Tony Antoniou, Muhammad M. Mamdani, J. Michael Paterson, Wim van den Brink

Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: An individual participant data meta-analysis

Caroline A. Crowther, Philippa F. Middleton, Merryn Voysey, Lisa Askie, Lelia Duley, Peter G. Pryde, Stéphane Marret, Lex W. Doyle, for the AMICABLE Group

Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial

Selidji T. Agnandji, José F. Fernandes, Emmanuel B. Bache, Régis M. Obiang Mba, Jessica S. Brosnahan, Lumeka Kabwende, Paul Pitzinger, Pieter Staarink, Marguerite Massinga-Loembe, Verena Krähling, Nadine Biedenkopf, Sarah Katharina Fehling, Thomas Strecker, David J. Clark, Henry M. Staines, Jay W. Hooper, Peter Silvera, Vasee Moorthy, Marie-Paule Kieny, Akim A. Adegnika, Martin P. Grobusch, Stephan Becker, Michael Ramharter, Benjamin Mordmüller, Bertrand Lell, VEBCON Consortium, Sanjeev Krishna, Peter G. Kremsner

Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin

Celia Dechavanne, Sebastien Dechavanne, Ibrahim Sadissou, Adjimon Gatien Lokossou, Fernanda Alvarado, Magalie Dambrun, Kabirou Moutairou, David Courtin, Gregory Nuel, Andre Garcia, Florence Migot-Nabias, Christopher L. King

The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study

Adam Shardlow, Natasha J. McIntyre, Simon D. S. Fraser, Paul Roderick, James Raftery, Richard J. Fluck, Christopher W. McIntyre, Maarten W. Taal

A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study

Fumiaki Imamura, Stephen J. Sharp, Albert Koulman, Matthias B. Schulze, Janine Kröger, Julian L. Griffin, José M. Huerta, Marcela Guevara, Ivonne Sluijs, Antonio Agudo, Eva Ardanaz, Beverley Balkau, Heiner Boeing, Veronique Chajes, Christina C. Dahm, Courtney Dow, Guy Fagherazzi, Edith J. M. Feskens, Paul W. Franks, Diana Gavrila, Marc Gunter, Rudolf Kaaks, Timothy J. Key, Kay-Tee Khaw, Tilman Kühn, Olle Melander, Elena Molina-Portillo, Peter M. Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, Salvatore Panico, Olov Rolandsson, Sabina Sieri, Carlotta Sacerdote, Nadia Slimani, Annemieke M. W. Spijkerman, Anne Tjønneland, Rosario Tumino, Yvonne T. van der Schouw, Claudia Langenberg, Elio Riboli, Nita G. Forouhi, Nick J. Wareham

Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults

Kazem Rahimi, Hamid Mohseni, Catherine M. Otto, Nathalie Conrad, Jenny Tran, Milad Nazarzadeh, Mark Woodward, Terence Dwyer, Stephen MacMahon

Tuberculosis detection and the challenges of integrated care in rural China: A cross-sectional standardized patient study

Sean Sylvia, Hao Xue, Chengchao Zhou, Yaojiang Shi, Hongmei Yi, Huan Zhou, Scott Rozelle, Madhukar Pai, Jishnu Das

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Benefit and harm of intensive blood pressure treatment: Derivation and validation of risk models using data from the SPRINT and ACCORD trials

Sanjay Basu, Jeremy B. Sussman, Joseph Rigdon, Lauren Steimle, Brian T. Denton, Rodney A. Hayward

A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial

Kristina Keitel, Frank Kagoro, Josephine Samaka, John Masimba, Zamzam Said, Hosiana Temba, Tarsis Mlaganile, Willy Sangu, Clotilde Rambaud-Althaus, Alain Gervaix, Blaise Genton, Valérie D’Acremont

Effectiveness of cervical screening after age 60 years according to screening history: Nationwide cohort study in Sweden

Jiangrong Wang, Bengt Andrae, Karin Sundström, Alexander Ploner, Peter Ström, K. Miriam Elfström, Joakim Dillner, Pär Sparén

Impact of disinvestment from weekend allied health services across acute medical and surgical wards: 2 stepped-wedge cluster randomised controlled trials

Terry P. Haines, Kelly-Ann Bowles, Deb Mitchell, Lisa O’Brien, Donna Markham, Samantha Plumb, Kerry May, Kathleen Philip, Romi Haas, Mitchell N. Sarkies, Marcelle Ghaly, Melina Shackell, Timothy Chiu, Steven McPhail, Fiona McDermott, Elizabeth H. Skinner

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