Submit Now

Are you ready to submit your manuscript? Please review the submission guidelineseditorial and publishing policiesfigure guidelines, and table guidelines, and then refer to this checklist to ensure that you have gathered all the relevant information and that the manuscript is formatted appropriately.

All manuscripts must be submitted in the online submission system.

You must submit a  presubmission inquiry before submitting a full manuscript. For more information, read the  presubmission inquiry guidelines

Submission Checklist

License agreement

Have you read the license agreement and are you able to sign it on behalf of all the authors?

Cover letter

Have you prepared a cover letter explaining why you consider this manuscript suitable for publication in PLOS Medicine?

Author list

Are you ready to enter authors in the correct order in the system and make sure that names, institutions, and email addresses are correct?

Are all authors aware of and do they approve the submission of the manuscript, its content, authorship, and order of authorship?

All authors will be emailed a request to acknowledge that they are authors on the paper, that the work is original and has not been submitted elsewhere, and that they agree to the publishing and editorial policies of PLOS Medicine. In addition, all authors will be asked to specify the nature of their contribution to the submitted work, and whether they have any competing interests. Read the author contribution instructions in the Submission Guidelines.

The corresponding author must provide an ORCID iD at the time of submission by entering it in the user profile in the submission system. For more information about how to register for an ORCID iD and link it to Editorial Manager, watch this short video.

Human subjects research

  • Does your study comply with the guidelines of the Declaration of Helsinki?
  • Do you have a copy of the statement from the relevant institutional review board or ethics committee indicating their approval of the research reported in the manuscript?
  • If your submission contains content that could identify individual patients (such as photos, descriptions, pedigrees), do you have copies of informed consent forms from those patients? Have the patients been informed that under open access this published information can be used for any lawful purpose?


Have you prepared a statement indicating who funded the study, and the role of the funding agency in conducting the study and in preparing the manuscript? You will be asked to enter this into the relevant section of the submission form.

Manuscript file

Is the manuscript file in DOC, DOCX, RTF, PDF, or LaTeX?

Does your manuscript comply with the submission guidelines​?


Do your figures conform to the figure guidelines?

Have your original figures been created as EPS or TIFF files in a high enough resolution (300 ppi – 600 ppi) to provide for adequate review? Please note that individual files should not exceed 10 MB.

Supporting information

Does your supporting information meet our guidelines?


Do your references comply with our reference guidelines?


Have non-standard abbreviations been listed as well as defined in the text?


Clinical trials

If reporting a clinical trial have you provided the registration number, do you have a copy of the protocol that you can upload as supporting information, and are you reporting it according to the CONSORT guidelines? Have you completed and attached the CONSORT checklist and flow diagram?

Systematic reviews

If the study is a systematic review of randomized controlled trials, are you reporting it according to the PRISMA Guidelines? Have you included a PRISMA checklist and flow diagram? If there is a protocol, have you stated this within the Methods section and is it available to provide as a supporting information file?

Reporting guidelines

  • If the study describes a diagnostic technique, are you reporting it according to the STARD guidelines?
  • If reporting an epidemiological study are you reporting it according the STROBE requirements?
  • If the study includes microarray data, are you reporting it according to the MIAME guidelines and have you deposited the data in a public database?
  • If your study includes research on animals, are you reporting it according to the ARRIVE guidelines?
  • For other study designs, please see the EQUATOR site for reporting guidelines and use the appropriate guideline.

Statistical methods

Have you included detailed descriptions of the statistical methods used in your study and do you provide a measure of error for any data reported?

Related manuscripts

Are related manuscripts by any of the authors submitted or in press elsewhere? If so, have you included this information in your cover letter and are you prepared to provide PDFs as supporting information?

Suggested reviewers

Have you identified potential reviewers whose email addresses you can provide?

Magazine submissions

Have you included details of the competing interests and financial disclosure, as well as other essential information in the article file? Read the guidelines for the magazine section.

Revised Manuscripts

Are you submitting a revision? Read the guidelines for revised manuscripts.


Please contact if you have any questions.

Visitor Survey