Figures
Murine embryonic fibroblasts (MEFs) take up extracellular double-stranded (ds) RNA via class A scavenger receptors (SR-As).
Cells have a number of intracellular sensors that mediate dsRNA-induced antiviral responses. DeWitte-Orr et al. (doi:10.1371/journal.ppat.1000829) report that SR-As mediate entry of extracellular dsRNA at the cell surface, and subsequently deliver the dsRNA to the classic intracellular pathways. In this image, Alexafluor 488 labelled, in vitro transcribed dsRNA based from the West Nile virus genome (1,000 bp) is taken up by MEFs. The nucleus of the cell is stained with Hoescht 33258.
Image Credit: Stephanie DeWitte-Orr, McMaster University
Citation: (2010) PLoS Pathogens Issue Image | Vol. 6(3) March 2010. PLoS Pathog 6(3): ev06.i03. https://doi.org/10.1371/image.ppat.v06.i03
Published: March 26, 2010
Copyright: © 2010 Stephanie DeWitte-Orr. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cells have a number of intracellular sensors that mediate dsRNA-induced antiviral responses. DeWitte-Orr et al. (doi:10.1371/journal.ppat.1000829) report that SR-As mediate entry of extracellular dsRNA at the cell surface, and subsequently deliver the dsRNA to the classic intracellular pathways. In this image, Alexafluor 488 labelled, in vitro transcribed dsRNA based from the West Nile virus genome (1,000 bp) is taken up by MEFs. The nucleus of the cell is stained with Hoescht 33258.
Image Credit: Stephanie DeWitte-Orr, McMaster University