Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

Isabel M. Vincent; Darren J. Creek; Karl Burgess; Debra J. Woods; Richard J. S. Burchmore; Michael P. Barrett

doi:10.1371/journal.pntd.0001618

Loading metrics

Open Access

Peer-reviewed

Research Article

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

Isabel M. Vincent,

Affiliation The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Darren J. Creek,

Affiliations The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics Facility, University of Glasgow, Glasgow, United Kingdom
⨯
Karl Burgess,

Affiliations The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics Facility, University of Glasgow, Glasgow, United Kingdom
⨯
Debra J. Woods,

Affiliation Pfizer Animal Health, Pfizer Inc, Kalamazoo, Michigan, United States of America
⨯
Richard J. S. Burchmore,

Affiliations The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics Facility, University of Glasgow, Glasgow, United Kingdom
⨯
Michael P. Barrett

* E-mail: michael.barrett@glasgow.ac.uk

Affiliations The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Glasgow Polyomics Facility, University of Glasgow, Glasgow, United Kingdom
⨯

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

Isabel M. Vincent,
Darren J. Creek,
Karl Burgess,
Debra J. Woods,
Richard J. S. Burchmore,
Michael P. Barrett

Published: May 1, 2012
https://doi.org/10.1371/journal.pntd.0001618

Reader Comments (1)

Post a new comment on this article

0 Responses

13 Jun 2012
22:35 GMT
Most Recent

Figure 2 Corrections Posted by plosntds_team on 13 Jun 2012 at 22:35 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Trypanosoma
Is the Subject Area "Trypanosoma" applicable to this article?

Thanks for your feedback.
Drug metabolism
Is the Subject Area "Drug metabolism" applicable to this article?

Thanks for your feedback.
Metabolites
Is the Subject Area "Metabolites" applicable to this article?

Thanks for your feedback.
Metabolomics
Is the Subject Area "Metabolomics" applicable to this article?

Thanks for your feedback.
Cell metabolism
Is the Subject Area "Cell metabolism" applicable to this article?

Thanks for your feedback.
Trypanosoma brucei gambiense
Is the Subject Area "Trypanosoma brucei gambiense" applicable to this article?

Thanks for your feedback.
Metabolic pathways
Is the Subject Area "Metabolic pathways" applicable to this article?

Thanks for your feedback.
Nitriles
Is the Subject Area "Nitriles" applicable to this article?

Thanks for your feedback.