About the Authors

Franklin R. Toapanta

ftoapanta@medicine.umaryland.edu (FRT); Msztein@medicine.umaryland.edu (MBS)

Affiliations Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Paula J. Bernal

Affiliations Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Stephanie Fresnay

Affiliations Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Laurence S. Magder

Affiliation Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Thomas C. Darton

Affiliation Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Claire Jones

Affiliation Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Claire S. Waddington

Affiliation Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Christoph J. Blohmke

Affiliation Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Brian Angus

Affiliation Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

Myron M. Levine

Affiliations Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Andrew J. Pollard

Affiliation Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Marcelo B. Sztein

ftoapanta@medicine.umaryland.edu (FRT); Msztein@medicine.umaryland.edu (MBS)

Affiliations Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FRT PJB MBS. Performed the experiments: FRT PJB SF. Analyzed the data: LSM FRT PJB LSM MBS. Contributed reagents/materials/analysis tools: LSM. Wrote the paper: FRT PJB LSM TCD CSW CJB BA AJP MML MBS. Set up the challenge model and generated the clinical data: TCD CSW MML AJP. Collected and processed the PBMC specimens: TCD CSW CJ CJB BA. Performed statistical analysis using the Mixed Effects Model: LSM.